Pro- and anti-inflammatory cytokines and osteoclastogenesis-related factors in peri-implant diseases: systematic review and meta-analysis

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Autor(es): dc.contributorAlfenas Federal University (Unifal-MG)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorOliveira, Jovânia Alves-
Autor(es): dc.creatorde Oliveira Alves, Roberta-
Autor(es): dc.creatorNascimento, Isabella Mazarelo-
Autor(es): dc.creatorHidalgo, Marco Antonio Rimachi-
Autor(es): dc.creatorScarel-Caminaga, Raquel Mantuaneli-
Autor(es): dc.creatorCristina Pigossi, Suzane-
Data de aceite: dc.date.accessioned2025-08-21T21:22:05Z-
Data de disponibilização: dc.date.available2025-08-21T21:22:05Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12903-023-03072-1-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300623-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300623-
Descrição: dc.descriptionBackground: Pro- and anti-inflammatory cytokines are acknowledged, during inflammatory bone destruction, as key regulators of osteoclast and osteoblast differentiation and activity. However, evidence regarding the exact role of pro- and anti-inflammatory cytokines and osteoclastogenesis-related factors in peri-implant diseases is unclear. We aimed to execute a systematic review and meta-analysis about the pro- and anti-inflammatory cytokines and osteoclastogenesis-related factors levels in peri-implant diseases. Methods: The focused question was elaborated to summarize the levels of pro-and anti-inflammatory cytokines and osteoclastogenesis-related factors in tissue samples (mRNA) and biofluids (protein levels) of patients with/without peri-implant diseases. Electronic searches of the PubMed, Cochrane Controlled Trials Registry, Web of Science, EMBASE, Scopus and Google scholar databases were conducted for publications up to March 2023. Meta-analysis evaluating the mediator´s levels (protein levels by ELISA) in peri-implant crevicular fluid (PICF) were made. The effect size was estimated and reported as the mean difference. The 95% confidence interval was estimated for each mediator, and the pooled effect was determined significant if two-sided p-values < 0.05 were obtained. Results: Twenty-two publications were included in the systematic review (qualitative analysis), with nine of these subjected to meta-analyses (quantitative analysis). In the qualitative analysis, higher pro-inflammatory cytokines [Interleukin (IL)-1β, IL-6] and pro-osteoclastogenic mediator [Receptor Activator of Nuclear Factor-Kappa B ligand (RANKL)] levels were observed in PICF of individuals with peri-implant diseases in comparison to healthy individuals. Higher RANKL/osteoprotegerin (OPG) ratios were observed in PICF from individuals with peri-implant diseases in comparison to healthy individuals. Meta-analysis showed higher RANKL levels in diseased groups compared to controls. Conclusions: The results showed that the levels of IL-1β, IL-6, IL-10, and RANKL/OPG are not balanced in peri-implant disease, suggesting that these mediators are involved in the host osteo-immunoinflammatory response related to peri-implantitis.-
Descrição: dc.descriptionSchool of Dentistry Alfenas Federal University (Unifal-MG), Minas Gerais-
Descrição: dc.descriptionDepartment of Periodontology School of Dentistry School of Dentistry Federal University of Uberlândia - UFU Umuarama Campus, Bloco UMU4L, Pará Avenue, Minas Gerais-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry at Araraquara (FOAr/UNESP) UNESP- São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry at Araraquara (FOAr/UNESP) UNESP- São Paulo State University, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationBMC Oral Health-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBone resorption-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectDental implants-
Palavras-chave: dc.subjectPeri-implantitis-
Título: dc.titlePro- and anti-inflammatory cytokines and osteoclastogenesis-related factors in peri-implant diseases: systematic review and meta-analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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