Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

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Autor(es): dc.contributorUniversidade de Marília (UNIMAR)-
Autor(es): dc.contributorSchool of Food and Technology of Marília (FATEC)-
Autor(es): dc.contributorMedica Sur Clinic & Foundation-
Autor(es): dc.contributorNational Autonomous University of Mexico-
Autor(es): dc.contributorUniversity “Magna Graecia”-
Autor(es): dc.contributorUniversidade de Lisboa (iMed.ULisboa)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFaculdade de Medicina de Marília (FAMEMA)-
Autor(es): dc.creatorTauil, Raissa Bulaty-
Autor(es): dc.creatorGolono, Paula Takano-
Autor(es): dc.creatorde Lima, Enzo Pereira-
Autor(es): dc.creatorde Alvares Goulart, Ricardo-
Autor(es): dc.creatorGuiguer, Elen Landgraf-
Autor(es): dc.creatorBechara, Marcelo Dib-
Autor(es): dc.creatorNicolau, Claudia C. T.-
Autor(es): dc.creatorYanaguizawa Junior, José Luiz-
Autor(es): dc.creatorFiorini, Adriana M. R.-
Autor(es): dc.creatorMéndez-Sánchez, Nahum-
Autor(es): dc.creatorAbenavoli, Ludovico-
Autor(es): dc.creatorDireito, Rosa-
Autor(es): dc.creatorValente, Vitor Engrácia-
Autor(es): dc.creatorLaurindo, Lucas Fornari-
Autor(es): dc.creatorBarbalho, Sandra Maria-
Data de aceite: dc.date.accessioned2025-08-21T19:45:57Z-
Data de disponibilização: dc.date.available2025-08-21T19:45:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ph17101354-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300614-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300614-
Descrição: dc.descriptionMetabolic-Associated Fatty Liver Disease (MAFLD) is a clinical–pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which is considered a significant cause of liver conditions and contributes to an increased risk of death worldwide. Even though the possible causes of MAFLD can involve the interaction of genetics, hormones, and nutrition, lifestyle (diet and sedentary lifestyle) is the most influential factor in developing this condition. Polyphenols comprise many natural chemical compounds that can be helpful in managing metabolic diseases. Therefore, the aim of this review was to investigate the impact of oxidative stress, inflammation, mitochondrial dysfunction, and the role of polyphenols in managing MAFLD. Some polyphenols can reverse part of the liver damage related to inflammation, oxidative stress, or mitochondrial dysfunction, and among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, and silymarin. These compounds have actions in reducing plasma liver enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, and the HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, liver fat content, steatosis index, and fibrosis. On the other hand, they can improve HDL-c, adiponectin levels, and fibrogenesis markers. These results show that polyphenols are promising in the prevention and treatment of MAFLD.-
Descrição: dc.descriptionDepartment of Biochemistry and Pharmacology School of Medicine Universidade de Marília (UNIMAR), São Paulo-
Descrição: dc.descriptionPostgraduate Program in Structural and Functional Interactions in Rehabilitation School of Medicine Universidade de Marília (UNIMAR), São Paulo-
Descrição: dc.descriptionDepartment of Biochemistry and Nutrition School of Food and Technology of Marília (FATEC), São Paulo-
Descrição: dc.descriptionLiver Research Unit Medica Sur Clinic & Foundation-
Descrição: dc.descriptionFaculty of Medicine National Autonomous University of Mexico-
Descrição: dc.descriptionDepartment of Health Sciences University “Magna Graecia”, Viale Europa-
Descrição: dc.descriptionLaboratory of Systems Integration Pharmacology Clinical and Regulatory Science Research Institute for Medicines Universidade de Lisboa (iMed.ULisboa), Av. Prof. Gama Pinto-
Descrição: dc.descriptionAutonomic Nervous System Center School of Philosophy and Sciences São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Biochemistry and Pharmacology School of Medicine Faculdade de Medicina de Marília (FAMEMA), São Paulo-
Descrição: dc.descriptionResearch Coordination UNIMAR Charity Hospital Universidade de Marília (UNIMAR), São Paulo-
Descrição: dc.descriptionAutonomic Nervous System Center School of Philosophy and Sciences São Paulo State University, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationPharmaceuticals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectliver disease-
Palavras-chave: dc.subjectMAFLD-
Palavras-chave: dc.subjectmetabolic-associated fatty liver disease-
Palavras-chave: dc.subjectmitochondrial dysfunction-
Palavras-chave: dc.subjectoxidative stress-
Palavras-chave: dc.subjectpolyphenols-
Título: dc.titleMetabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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