Involvement of Pre-limbic Cortex-Nucleus accumbens projections in Context-Induced alcohol seeking

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Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.creatorBianchi, Paula Cristina-
Autor(es): dc.creatorPalombo, Paola-
Autor(es): dc.creatorEngi, Sheila Antonagi-
Autor(es): dc.creatorCarneiro de Oliveira, Paulo Eduardo-
Autor(es): dc.creatorTavares, Gabrielle Emily Boaventura-
Autor(es): dc.creatorAnjos-Santos, Alexia-
Autor(es): dc.creatorYokoyama, Thais Suemi-
Autor(es): dc.creatorPlaneta, Cleopatra da Silva-
Autor(es): dc.creatorCruz, Fábio Cardoso-
Autor(es): dc.creatorLeão, Rodrigo Molini-
Data de aceite: dc.date.accessioned2025-08-21T17:08:04Z-
Data de disponibilização: dc.date.available2025-08-21T17:08:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2024.149086-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300603-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300603-
Descrição: dc.descriptionAlcohol use disorder (AUD) remains a critical public health issue worldwide, characterized by high relapse rates often triggered by contextual cues. This research investigates the neural mechanisms behind context-induced reinstatement of alcohol-seeking behavior, focusing on the nucleus accumbens and its interactions with the prelimbic cortex, employing Male Long-Evans rats in an ABA renewal model. In our experimental setup, rats were trained to self-administer 10 % ethanol in Context A, followed by extinction of lever pressing in the presence of discrete cues in Context B. The context-induced reinstatement of ethanol-seeking was then assessed by re-exposing rats to Context A or B under extinction conditions, aiming to simulate the environmental cues’ influence on relapse behaviors. Three experiments were conducted: Experiment 1 utilized Fos-immunohistochemistry to examine neuronal activation in the nucleus accumbens; Experiment 2 applied the baclofen + muscimol inactivation technique to probe the functional importance of the nucleus accumbens core; Experiment 3 used Fos-immunofluorescence along with Retrobeads injection to investigate activation of neurons projecting from the prelimbic cortex to the nucleus accumbens core. Our findings revealed significant increases in Fos-immunoreactive nuclei within the nucleus accumbens core and shell during the reinstatement phase in Context A, underscoring the environment's potent effect on ethanol-seeking behavior. Additionally, inactivation of the nucleus accumbens core markedly reduced reinstatement, and there was a notable activation of neurons from the prelimbic cortex to the nucleus accumbens core in the ethanol-associated context. These results highlight the critical role of the nucleus accumbens core and its corticostriatal projections in the neural circuitry underlying context-driven ethanol seeking.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Behavioral Neuroscience Paulista Medicine School Universidade Federal de São Paulo-UNIFESP, SP-
Descrição: dc.descriptionLaboratory of Neuropsychopharmacology School of Pharmaceutical Sciences São Paulo State University UNESP, SP-
Descrição: dc.descriptionLaboratory of Pharmacology Biomedical Sciences Institute Department of Pharmacology Federal University of Uberlândia, MG-
Descrição: dc.descriptionGraduate Program in Genetics and Biochemistry Institute of Biotechnology Federal University of Uberlândia/MG-
Descrição: dc.descriptionLaboratory of Neuropsychopharmacology School of Pharmaceutical Sciences São Paulo State University UNESP, SP-
Descrição: dc.descriptionFAPESP: 2013/24986-2-
Descrição: dc.descriptionFAPESP: 2014/02296-7-
Descrição: dc.descriptionFAPESP: 2018/15505-4-
Idioma: dc.languageen-
Relação: dc.relationBrain Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlcohol-
Palavras-chave: dc.subjectPre-limbic Cortex-Nucleus Accumbens Projections-
Palavras-chave: dc.subjectRats-
Palavras-chave: dc.subjectReinstatement-
Palavras-chave: dc.subjectSelf-administration-
Título: dc.titleInvolvement of Pre-limbic Cortex-Nucleus accumbens projections in Context-Induced alcohol seeking-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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