Lateral hypothalamic astrocytes contribute to the hypercapnic chemoreflex in a light-dark cycle-dependent manner in unanesthetized rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRosatti, Marcelo Rafanelli-
Autor(es): dc.creatorGargaglioni, Luciane H.-
Autor(es): dc.creatorDias, Mirela B.-
Data de aceite: dc.date.accessioned2025-08-21T20:24:32Z-
Data de disponibilização: dc.date.available2025-08-21T20:24:32Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.resp.2024.104352-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300591-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300591-
Descrição: dc.descriptionBrainstem astrocytes are important for CO2/H+ chemoreception. Lateral Hypothalamus/Perifornicial Area (LH/PFA) neurons have an excitatory effect on the ventilatory response to CO2, however the role of the astrocytes is unknown. We hypothesized that LH/PFA astrocytes play an excitatory role in the hypercapnic ventilatory response in a sleep-wake and light-dark cycles-dependent manner. We manipulated the activity of astrocytes in the LH/PFA of male Wistar rats through microinjection of Fluorocitrate (Fct), which selectively affects astrocytes, inducing the exocytosis of gliotransmitters. We investigated the effects of intra-LH/PFA Fct microinjection on resting breathing and ventilatory responses to hypercapnia and hypoxia during wakefulness and NREM sleep, in the light and dark phases. Fct increased ventilation during hypercapnia but not during room air or hypoxia. The hypercapnic chemoreflex was increased exclusively during the dark-active phase during both, wakefulness and NREM sleep, indicating that LH/PFA astrocytes play an excitatory role in hypercapnic ventilatory response in a light-dark cycle-dependent manner.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Physiology Institute of Bioscience Sao Paulo State University-UNESP, SP-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology Sao Paulo State University-FCAV, Jaboticabal, SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Physiology Institute of Bioscience Sao Paulo State University-UNESP, SP-
Descrição: dc.descriptionDepartment of Animal Morphology and Physiology Sao Paulo State University-FCAV, Jaboticabal, SP-
Descrição: dc.descriptionFAPESP: 2019/17693–5-
Descrição: dc.descriptionFAPESP: 2020/02437–0-
Idioma: dc.languageen-
Relação: dc.relationRespiratory Physiology and Neurobiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAstrocytes-
Palavras-chave: dc.subjectBreathing-
Palavras-chave: dc.subjectHypercapnia-
Palavras-chave: dc.subjectLateral hypothalamus-
Palavras-chave: dc.subjectLight-dark cycle-
Título: dc.titleLateral hypothalamic astrocytes contribute to the hypercapnic chemoreflex in a light-dark cycle-dependent manner in unanesthetized rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.