Silver Nanoparticle-Embedded Carbon Nitride: Antifungal Activity on Candida albicans and Toxicity toward Animal Cells

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSaveetha Institute of Medical and Technical Sciences (SIMTS)-
Autor(es): dc.contributorInstitute of Nanoscience and Technology-
Autor(es): dc.contributorUniversidad Adolfo Ibáñez-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorArumugam, Ganeshkumar-
Autor(es): dc.creatorDurairaj, Sivaraj-
Autor(es): dc.creatorGonçale, Juliana Caparroz-
Autor(es): dc.creatorFonseca do Carmo, Paulo Henrique-
Autor(es): dc.creatorTerra Garcia, Maíra-
Autor(es): dc.creatorSoares da Silva, Newton-
Autor(es): dc.creatorBorges, Bruno Montanari-
Autor(es): dc.creatorLoures, Flavio Vieira-
Autor(es): dc.creatorGhosh, Deepa-
Autor(es): dc.creatorVivanco, Juan F.-
Autor(es): dc.creatorJunqueira, Juliana Campos-
Data de aceite: dc.date.accessioned2025-08-21T16:31:30Z-
Data de disponibilização: dc.date.available2025-08-21T16:31:30Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-22-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acsami.4c02694-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300567-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300567-
Descrição: dc.descriptionThe development of engineered nanomaterials has been considered a promising strategy to control oral infections. In this study, silver-embedded carbon nitrides (Ag@g-CN) were synthesized and tested against Candida albicans, investigating their antifungal action and biocompatibility in animal cells. Ag@g-CN was synthesized by a simple one-pot thermal polymerization technique and characterized by various analytical techniques. X-ray diffraction (XRD) analysis revealed slight alterations in the crystal structure of g-CN upon the incorporation of Ag. Fourier transform infrared (FT-IR) spectroscopy confirmed the presence of Ag-N bonds, indicating successful silver incorporation and potential interactions with g-CN’s amino groups. UV-vis spectroscopy demonstrated a red shift in the absorption edge of Ag@g-CN compared with g-CN, attributed to the surface plasmon resonance effect of silver nanoparticles. Field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) confirmed the 2D layered sheet like morphology of both materials. The Ag 3d peaks found in X-ray photoelectron spectroscopy (XPS) confirmed the presence of metallic Ag0 nanoparticles in Ag@g-CN. The Ag@g-CN materials exhibited high antifungal activity against reference and oral clinical strains of C. albicans, with minimal inhibitory concentration (MIC) ranges between 16-256 μg/mL. The mechanism of Ag@g-CN on C. albicans was attributed to the disruption of the membrane integrity and disturbance of the biofilm. In addition, the Ag@g-CN material showed good biocompatibility in the fibroblastic cell line and in Galleria mellonella, with no apparent cytotoxicity observed at a concentration up to 1000 μg/mL. These findings demonstrate the potential of the Ag@g-CN material as an effective and safe antifungal agent for the treatment of oral fungal infections.-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University/UNESP, São José dos Campos-
Descrição: dc.descriptionDepartment of Materials Physics Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMTS), Thandalam, Tamil Nadu-
Descrição: dc.descriptionChemical Biology Unit Institute of Nanoscience and Technology, Knowledge City, Sector 81, Punjab-
Descrição: dc.descriptionFaculty of Engineering and Sciences Universidad Adolfo Ibáñez-
Descrição: dc.descriptionInstitute of Science and Technology Federal University of São Paulo/UNIFESP, São José dos Campos-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University/UNESP, São José dos Campos-
Formato: dc.format25727-25739-
Idioma: dc.languageen-
Relação: dc.relationACS Applied Materials and Interfaces-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject2D material-
Palavras-chave: dc.subjectantifungal properties-
Palavras-chave: dc.subjectbiocompatibility-
Palavras-chave: dc.subjectC. albicans-
Palavras-chave: dc.subjectcarbon nitrides-
Palavras-chave: dc.subjectone-pot thermal polymerization-
Título: dc.titleSilver Nanoparticle-Embedded Carbon Nitride: Antifungal Activity on Candida albicans and Toxicity toward Animal Cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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