Potential role of uric acid to activate NLRP3 inflammasome triggering endothelial dysfunction in preeclampsia

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorNunes, Priscila Rezeck-
Autor(es): dc.creatorRomao-Veiga, Mariana-
Autor(es): dc.creatorPeracoli, Maria Terezinha Serrao-
Autor(es): dc.creatorPeracoli, Jose Carlos-
Autor(es): dc.creatorSandrim, Valeria Cristina-
Data de aceite: dc.date.accessioned2025-08-21T23:21:56Z-
Data de disponibilização: dc.date.available2025-08-21T23:21:56Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.clicom.2022.03.003-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300561-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300561-
Descrição: dc.descriptionPreeclampsia (PE) is a pregnancy-related disorder associated with increasing maternal death rates and affecting 2–8% of pregnant women worldwide. Arterial hypertension and proteinuria, followed by other maternal dysfunctions are classic clinical parameters to identify this disease. Furthermore, hyperuricemia is strictly related to PE, and high plasmatic levels of uric acid have been associated with disease severity. The inflammation in the endothelium caused by danger signals, such as uric acid crystals, is persistent and stimulates the release of inflammatory cytokines, and activates the NLRP3 inflammasome. The mechanisms underlying endothelial dysfunction induced by the metabolism of uric acid, and consequently increased levels of inflammation and oxidative stress in women with PE could be ameliorated with interventions related to inhibition of the NLRP3 activation MSU-mediated and may improve the prognostics of this disease.-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University (Unesp)-
Formato: dc.format69-75-
Idioma: dc.languageen-
Relação: dc.relationClinical Immunology Communications-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEndothelial dysfunction-
Palavras-chave: dc.subjectHyperuricemia-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectNLRP3-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectPreeclampsia-
Palavras-chave: dc.subjectUric acid-
Título: dc.titlePotential role of uric acid to activate NLRP3 inflammasome triggering endothelial dysfunction in preeclampsia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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