Macrophage Cell Membrane Coating on Piperine-Loaded MIL-100(Fe) Nanoparticles for Breast Cancer Treatment

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorHospital Clinico San Carlos and Health Research Institute of the Hospital Clinico San Carlos-
Autor(es): dc.contributorUniversidad de Castilla-La Mancha-
Autor(es): dc.creatorQuijia, Christian Rafael-
Autor(es): dc.creatorNavegante, Geovana-
Autor(es): dc.creatorSábio, Rafael Miguel-
Autor(es): dc.creatorValente, Valeria-
Autor(es): dc.creatorOcaña, Alberto-
Autor(es): dc.creatorAlonso-Moreno, Carlos-
Autor(es): dc.creatorFrem, Regina Célia Galvão-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T15:49:24Z-
Data de disponibilização: dc.date.available2025-08-21T15:49:24Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jfb14060319-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300522-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300522-
Descrição: dc.descriptionPiperine (PIP), a compound found in Piper longum, has shown promise as a potential chemotherapeutic agent for breast cancer. However, its inherent toxicity has limited its application. To overcome this challenge, researchers have developed PIP@MIL-100(Fe), an organic metal–organic framework (MOF) that encapsulates PIP for breast cancer treatment. Nanotechnology offers further treatment options, including the modification of nanostructures with macrophage membranes (MM) to enhance the evasion of the immune system. In this study, the researchers aimed to evaluate the potential of MM-coated MOFs encapsulated with PIP for breast cancer treatment. They successfully synthesized MM@PIP@MIL-100(Fe) through impregnation synthesis. The presence of MM coating on the MOF surface was confirmed through SDS-PAGE analysis, which revealed distinct protein bands. Transmission electron microscopy (TEM) images demonstrated the existence of a PIP@MIL-100(Fe) core with a diameter of around 50 nm, surrounded by an outer lipid bilayer layer measuring approximately 10 nm in thickness. Furthermore, the researchers evaluated the cytotoxicity indices of the nanoparticles against various breast cancer cell lines, including MCF-7, BT-549, SKBR-3, and MDA. The results demonstrated that the MOFs exhibited between 4 and 17 times higher cytotoxicity (IC50) in all four cell lines compared to free PIP (IC50 = 193.67 ± 0.30 µM). These findings suggest that MM@PIP@MIL-100(Fe) holds potential as an effective treatment for breast cancer. The study’s outcomes highlight the potential of utilizing MM-coated MOFs encapsulated with PIP as an innovative approach for breast cancer therapy, offering improved cytotoxicity compared to free PIP alone. Further research and development are warranted to explore the clinical translation and optimize the efficacy and safety of this treatment strategy.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionJunta de Comunidades de Castilla-La Mancha-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara Jau, Km 01-s/n-Campos Ville-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara Jau, Km 01-s/n-Campos Ville-
Descrição: dc.descriptionDepartment of Medical Oncology Hospital Clinico San Carlos and Health Research Institute of the Hospital Clinico San Carlos-
Descrição: dc.descriptionUnidad NanoDrug Facultad de Farmacia Universidad de Castilla-La Mancha-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), Prof. Francisco Degni 55-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara Jau, Km 01-s/n-Campos Ville-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara Jau, Km 01-s/n-Campos Ville-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), Prof. Francisco Degni 55-
Descrição: dc.descriptionFAPESP: 2018/21119–0-
Descrição: dc.descriptionJunta de Comunidades de Castilla-La Mancha: SBPLY/21/180501/000050-
Idioma: dc.languageen-
Relação: dc.relationJournal of Functional Biomaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcytotoxicity-
Palavras-chave: dc.subjectmetal–organic framework-
Palavras-chave: dc.subjectnanostructures-
Palavras-chave: dc.subjectvesicle-
Título: dc.titleMacrophage Cell Membrane Coating on Piperine-Loaded MIL-100(Fe) Nanoparticles for Breast Cancer Treatment-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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