Insights into the global genomic features of Salmonella enterica serovar Gallinarum biovars Gallinarum and Pullorum

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorCampos, Isabela C-
Autor(es): dc.creatorVilela, Felipe Pinheiro-
Autor(es): dc.creatorSaraiva, Mauro De M. S-
Autor(es): dc.creatorJunior, Angelo Berchieri-
Autor(es): dc.creatorFalcão, Juliana Pfrimer-
Data de aceite: dc.date.accessioned2025-08-21T21:41:49Z-
Data de disponibilização: dc.date.available2025-08-21T21:41:49Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/jambio/lxae217-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300513-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300513-
Descrição: dc.descriptionAims: Characterize global genomic features of 86 genomes of Salmonella Gallinarum (SG) and Pullorum (SP), which are important pathogens causing systemic infections in poultry. Methods and results: All genomes harbored efflux pump encoding gene mdsA and gold tolerance genes golS and golT. Aminoglycoside (aac(6′)-Ib, aadA5, aph(6)-Id, aph(3′')-Ib, ant(2′')-Ia), beta-lactam (blaTEM-1, blaTEM-135), efflux pump (mdsB), fosfomycin (fosA3), sulfonamide (sul1, sul2), tetracycline [tet(A)], trimethoprim (dfrA17), acid (asr), and disinfectant (qacEdelta1) resistance genes, gyrA, gyrB, and parC quinolone resistance point mutations, and mercury tolerance genes (mer) were found in different frequencies. Additionally, 310 virulence genes, pathogenicity islands (including SPI-1, 2, 3, 4, 5, 6, 9, 10, 12, 13, and 14), plasmids [IncFII(S), ColpVC, IncX1, IncN, IncX2, and IncC], and prophages (Fels-2, ST104, 500465-1, pro483, Gifsy-2, 103 203_sal5, Fels-1, RE-2010, vB_SenS-Ent2, and L-413C) were detected. MLST showed biovar-specific sequence types, and core genome MLST showed country-specific and global-related clusters. Conclusion: SG and SP global strains carry many virulence factors and important antimicrobial resistance genes. The diverse plasmids and prophages suggest genetic variability. MLST and cgMLST differentiated biovars and showed profiles occurring locally or worldwide.-
Descrição: dc.descriptionDepartment of Pathology Reproduction and One Health School of Agriculture and Veterinarian Sciences São Paulo State University, Via de Acesso Prof. Paulo Donato Castellane, s/n, SP-
Descrição: dc.descriptionDepartment of Clinical Analyses Toxicology and Food Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo, Av. Prof. Dr. Zeferino Vaz, s/n, Campus da USP, SP-
Descrição: dc.descriptionDepartment of Pathology Reproduction and One Health School of Agriculture and Veterinarian Sciences São Paulo State University, Via de Acesso Prof. Paulo Donato Castellane, s/n, SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectfowl typhoid-
Palavras-chave: dc.subjectpoultry-
Palavras-chave: dc.subjectpullorum disease-
Palavras-chave: dc.subjectSalmonella Gallinarum-
Palavras-chave: dc.subjectSalmonella Pullorum-
Palavras-chave: dc.subjectwhole-genome sequencing-
Título: dc.titleInsights into the global genomic features of Salmonella enterica serovar Gallinarum biovars Gallinarum and Pullorum-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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