Socket preservation utilizing polymeric bioresorbable membranes: a preclinical model

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Miami Miller School of Medicine-
Autor(es): dc.contributorUniversidad de la Frontera-
Autor(es): dc.contributorUniversity of La Frontera-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPrivate Practice-
Autor(es): dc.contributorNYU Dentistry-
Autor(es): dc.contributorNYU Grossman School of Medicine-
Autor(es): dc.contributorNYU Tandon School of Engineering-
Autor(es): dc.creatorSousa, Edisa Oliveira-
Autor(es): dc.creatorMirsky, Nicholas A.-
Autor(es): dc.creatorParra, Marcelo-
Autor(es): dc.creatorNayak, Vasudev Vivekanand-
Autor(es): dc.creatorSilva, Bruno Luís Graciliano-
Autor(es): dc.creatorBonfante, Estevam A.-
Autor(es): dc.creatorTovar, Nick-
Autor(es): dc.creatorCoelho, Paulo G.-
Autor(es): dc.creatorWitek, Lukasz-
Data de aceite: dc.date.accessioned2025-08-21T21:53:57Z-
Data de disponibilização: dc.date.available2025-08-21T21:53:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4317/medoral.26938-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300502-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300502-
Descrição: dc.descriptionBackground: The preservation of the alveolar ridge following tooth extraction is crucial to prevent atrophy and maintain structural integrity, facilitating future dental rehabilitations. This study compared the use of two different polymeric, resorbable membranes: polylactic acid (PLA), and 5% polylactic acid + 95% polycaprolactone (PLA/PCL), relative to unassisted socket healing (negative control). Material and Methods: A preclinical model involving healthy, skeletally mature beagles (n=7) were used in this study. Surface topography and thermal degradation of the membranes were assessed, followed by in vivo evaluation of socket preservation in extracted maxillary premolars. Histomorphometric analysis was employed to measure bone formation and total socket area. Data was analyzed through linear mixed models with fixed factor of treatment following a post-hoc comparison by the Tukey test. Ranked data of residual membrane presence and inflammatory infiltrate were analyzed through Kruskal-Wallis non-parametric test. All analyses were conducted with statistical significance set at p-value ≤ 0.05. Results: Surface topography depicted a distinctive fibrous network structure for PLA membrane relative to PLA/PCL which exhibited a more porous architecture. Thermal degradation behavior/profile, observed through TGA and DSC, for both membranes was similar. Histomorphometric analysis of bone formation within the induced socket yielded 36.1 ±7.7%, 35.6 ±7.2% and 32.8 ±7.7% for control, PLA and PLA/PCL groups, respectively, with no statistically significant differences between groups (p = 0.796). Analysis of total socket area (mean ± 95% confidence intervals) yielded significantly higher values for experimental groups, PLA (8.95 ± 1.7 mm2) and PLA/PCL (8.8 ± 1.76 mm2), relative to control (6.7 ± 1.8 mm2) (p = 0.041). Residual membrane, along with mild inflammatory infiltrate was observed after the healing period irrespective of membrane type utilized. Conclusions: Guided bone regeneration (GBR) with PLA and PLA/PCL membranes did not yield higher bone formation within the socket relative to the control group. However, an improvement in the preservation of the socket’s architecture was observed.-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontology Bauru School of Dentistry University of Sao Paulo-
Descrição: dc.descriptionUniversity of Miami Miller School of Medicine-
Descrição: dc.descriptionDepartment of Comprehensive Adult Dentistry Faculty of Dentistry Universidad de la Frontera-
Descrição: dc.descriptionCenter of Excellence in Morphological and Surgical Studies (CEMyQ) Faculty of Medicine University of La Frontera-
Descrição: dc.descriptionDepartment of Biochemistry and Molecular Biology University of Miami Miller School of Medicine-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry of Araraquara São Paulo State University (UNESP)-
Descrição: dc.descriptionPrivate Practice-
Descrição: dc.descriptionDeWitt Daughtry Family Department of Surgery Division of Plastic and Reconstructive Surgery University of Miami Miller School of Medicine-
Descrição: dc.descriptionBiomaterials Division NYU Dentistry-
Descrição: dc.descriptionHansjörg Wyss Department of Plastic Surgery NYU Grossman School of Medicine-
Descrição: dc.descriptionDepartment of Biomedical Engineering NYU Tandon School of Engineering, Brooklyn-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry of Araraquara São Paulo State University (UNESP)-
Formato: dc.format288-296-
Idioma: dc.languageen-
Relação: dc.relationMedicina Oral Patologia Oral y Cirugia Bucal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlveolar ridge preservation-
Palavras-chave: dc.subjectguided bone regeneration-
Palavras-chave: dc.subjectpolycaprolactone-
Palavras-chave: dc.subjectpolylactic acid-
Palavras-chave: dc.subjectresorbable membranes-
Título: dc.titleSocket preservation utilizing polymeric bioresorbable membranes: a preclinical model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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