Long exposure to a mixture of endocrine disruptors prediposes the ventral prostate of rats to preneoplastic lesions

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorHenry Ford Health-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSousa, Thaina Cavalleri-
Autor(es): dc.creatorde Souza, Letícia Pereira-
Autor(es): dc.creatorRicardo, Maria Luiza Silva-
Autor(es): dc.creatorYoshigae, Andreia Yuri-
Autor(es): dc.creatorHinokuma, Karianne Delalibera-
Autor(es): dc.creatorGorzoni, Ana Beatriz Ratto-
Autor(es): dc.creatorde Aquino, Ariana Musa-
Autor(es): dc.creatorScarano, Wellerson Rodrigo-
Autor(es): dc.creatorde Sousa Castillho, Anthony César-
Autor(es): dc.creatorTavares, Maria Eduarda Almeida-
Autor(es): dc.creatorVeras, Alice Santos Cruz-
Autor(es): dc.creatorTeixeira, Giovana Rampazzo-
Autor(es): dc.creatorNai, Gisele Alborghetti-
Autor(es): dc.creatorde Oliveira Mendes, Leonardo-
Data de aceite: dc.date.accessioned2025-08-21T15:31:38Z-
Data de disponibilização: dc.date.available2025-08-21T15:31:38Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11356-023-29768-z-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300493-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300493-
Descrição: dc.descriptionEndocrine disruptors (ED) are compounds dispersed in the environment that modify hormone biosynthesis, affecting hormone-dependent organs such as the prostate. Studies have only focused on evaluating the effects of ED alone or in small groups and short intervals and have not adequately portrayed human exposure. Therefore, we characterized the prostate histoarchitecture of rats exposed to an ED mixture (ED Mix) mimicking human exposure. Pregnant females of the Sprague–Dawley strain were randomly distributed into two experimental groups: Control group (vehicle: corn oil, by gavage) and ED Mix group: received 32.11 mg/kg/day of the ED mixture diluted in corn oil (2 ml/kg), by gavage, from gestational day 7 (DG7) to post-natal day 21 (DPN21). After weaning at DPN22, the male pups continued to receive the complete DE mixture until they were 220 days old when they were euthanized. The ED Mix decreased the epithelial compartment, increased the fractal dimension, and decreased glandular dilation. In addition, low-grade prostatic intraepithelial neoplasia was observed in addition to regions of epithelial atrophy in the group exposed to the ED Mix. Exposure to the mixture decreased both types I and III collagen area in the stroma. We concluded that the ED Mix was able to cause alterations in the prostatic histoarchitecture and induce the appearance of preneoplastic lesions.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionGraduate Program in Animal Science Western São Paulo University (UNOESTE), Rodovia Raposo Tavares, Km 572 - Bairro Do Limoeiro, SP-
Descrição: dc.descriptionFaculty of Healthy Sciences Western São Paulo University (UNOESTE), R. José Bongiovani, 700 - Cidade Universitária, SP-
Descrição: dc.descriptionHenry Ford Cancer Institute Henry Ford Health-
Descrição: dc.descriptionDepartment of Functional and Structural Biology IBB/UNESP, Rubião Junior, SP-
Descrição: dc.descriptionExperimental Laboratory of Exercise Biology (LEBioEx) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionGraduate Program in Health Science Western São Paulo University (UNOESTE), Rodovia Raposo Tavares, km 572 – Bairro do Limoeiro, SP-
Descrição: dc.descriptionDepartment of Functional and Structural Biology IBB/UNESP, Rubião Junior, SP-
Descrição: dc.descriptionExperimental Laboratory of Exercise Biology (LEBioEx) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 2018/24044-0-
Formato: dc.format104015-104028-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Science and Pollution Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCollagen-
Palavras-chave: dc.subjectEcotoxicology-
Palavras-chave: dc.subjectEndocrine disruptors-
Palavras-chave: dc.subjectEnvironmental exposure-
Palavras-chave: dc.subjectProstate gland-
Palavras-chave: dc.subjectProstatic intraepithelial neoplasia-
Título: dc.titleLong exposure to a mixture of endocrine disruptors prediposes the ventral prostate of rats to preneoplastic lesions-
Tipo de arquivo: dc.typelivro digital-
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