Can exposure to lisdexamfetamine dimesylate from juvenile period to peripubertal compromise male reproductive parameters in adult rats?

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorStein, Julia-
Autor(es): dc.creatorJorge, Bárbara Campos-
Autor(es): dc.creatorNagaoka, Lívia Trippe-
Autor(es): dc.creatorReis, Ana Carolina Casali-
Autor(es): dc.creatorManoel, Beatriz de Matos-
Autor(es): dc.creatorGodoi, Alana Rezende-
Autor(es): dc.creatorFioravante, Vanessa Caroline-
Autor(es): dc.creatorMartinez, Francisco Eduardo-
Autor(es): dc.creatorPinheiro, Patrícia Fernanda Felipe-
Autor(es): dc.creatorPupo, André Sampaio-
Autor(es): dc.creatorArena, Arielle Cristina-
Data de aceite: dc.date.accessioned2025-08-21T16:27:53Z-
Data de disponibilização: dc.date.available2025-08-21T16:27:53Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.taap.2024.116867-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300484-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300484-
Descrição: dc.descriptionLisdexamfetamine (LDX) is a d-amphetamine prodrug used to treat attention deficit and hyperactivity disorder, a common neurodevelopmental disorder in children and adolescents. Due to its action mediated by elevated levels of catecholamines, mainly dopamine and noradrenaline, which influence hormonal regulation and directly affect the gonads, this drug may potentially disrupt reproductive performance. This study evaluated the effects of exposure to LDX from the juvenile to peripubertal period (critical stages of development) on systemic and reproductive toxicity parameters in male rats. Male Wistar rats (23 days old) were treated with 0; 5.2; 8.6 or 12.1 mg/kg/day of LDX from post-natal day (PND) 23 to 53, by gavage. LDX treatment led to reduced daily food and water consumption, as well as a decrease in social behaviors. The day of preputial separation remained unaltered, although the treated animals exhibited reduced weight. At PND 54, the treated animals presented signs of systemic toxicity, evidenced by a reduction in body weight gain, increase in the relative weight of the liver, spleen, and seminal gland, reduction in erythrocyte and leukocyte counts, reduced total protein levels, and disruptions in oxidative parameters. In adulthood, there was an increase in immobile sperm, reduced sperm count, morphometric changes in the testis, and altered oxidative parameters, without compromising male sexual behavior and fertility. These findings showed that LDX-treatment during the juvenile and peripubertal periods induced immediate systemic toxicity and adversely influenced reproductive function in adult life, indicating that caution is necessary when prescribing this drug during the peripubertal phase.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Morphology sector Institute of Biosciences of Botucatu São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Anatomy sector Institute of Biosciences of Botucatu São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionCenter of Information and Toxicological Assistance (CIATOX) Institute of Biosciences of Botucatu São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Morphology sector Institute of Biosciences of Botucatu São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Anatomy sector Institute of Biosciences of Botucatu São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionCenter of Information and Toxicological Assistance (CIATOX) Institute of Biosciences of Botucatu São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFAPESP: 2021/02225-6-
Descrição: dc.descriptionFAPESP: 2021/04119-9-
Descrição: dc.descriptionCAPES: 88887.602916/2021-00-
Idioma: dc.languageen-
Relação: dc.relationToxicology and Applied Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHepatotoxicity-
Palavras-chave: dc.subjectLisdexamfetamine dimesylate-
Palavras-chave: dc.subjectReproductive toxicity-
Palavras-chave: dc.subjectSperm disturbances-
Palavras-chave: dc.subjectStimulants-
Palavras-chave: dc.subjectSystemic toxicity-
Título: dc.titleCan exposure to lisdexamfetamine dimesylate from juvenile period to peripubertal compromise male reproductive parameters in adult rats?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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