Genome-wide scans identify biological and metabolic pathways regulating carcass and meat quality traits in beef cattle

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Jequitinhonha and Mucuri Valleys-
Autor(es): dc.contributorUniversity of Viçosa-
Autor(es): dc.contributorNational Council for Science and Technological Development-
Autor(es): dc.creatorArikawa, Leonardo Machestropa-
Autor(es): dc.creatorMota, Lucio Flavio Macedo-
Autor(es): dc.creatorSchmidt, Patrícia Iana-
Autor(es): dc.creatorFrezarim, Gabriela Bonfá-
Autor(es): dc.creatorFonseca, Larissa Fernanda Simielli-
Autor(es): dc.creatorMagalhães, Ana Fabrícia Braga-
Autor(es): dc.creatorSilva, Delvan Alves-
Autor(es): dc.creatorCarvalheiro, Roberto-
Autor(es): dc.creatorChardulo, Luis Artur Loyola-
Autor(es): dc.creatorAlbuquerque, Lucia Galvão de-
Data de aceite: dc.date.accessioned2025-08-21T22:43:42Z-
Data de disponibilização: dc.date.available2025-08-21T22:43:42Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.meatsci.2023.109402-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300475-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300475-
Descrição: dc.descriptionGenome association studies (GWAS) provides knowledge about the genetic architecture of beef-related traits that allow linking the target phenotype to genomic information aiding breeding decision. Thus, the present study aims to uncover the genetic mechanism involved in carcass (REA: rib eye area, BF: backfat thickness, and HCW: hot carcass weight) and meat quality traits (SF: shear-force, MARB: marbling score, and IMF: intramuscular fat content) in Nellore cattle. For this, 6910 young bulls with phenotypic information and 23,859 animals genotyped with 435 k markers were used to perform the weighted single-step GBLUP (WssGBLUP) approach, considering two iterations. The top 10 genomic regions explained 8.13, 11.81, and 9.58% of the additive genetic variance, harboring a total of 119, 143, and 95 positional candidate genes for REA, BF, and HCW, respectively. For meat quality traits, the top 10 windows explained a large proportion of the total genetic variance for SF (14.95%), MARB (17.56%), and IMF (21.41%) surrounding 92, 155, and 111 candidate genes, respectively. Relevant candidate genes (CAST, PLAG1, XKR4, PLAGL2, AQP3/AQP7, MYLK2, WWOX, CARTPT, and PLA2G16) are related to physiological aspects affecting growth, carcass, meat quality, feed intake, and reproductive traits by signaling pathways controlling muscle control, key signal metabolic molecules INS / IGF-1 pathway, lipid metabolism, and adipose tissue development. The GWAS results provided insights into the genetic control of the traits studied and the genes found are potential candidates to be used in the improvement of carcass and meat quality traits.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Agricultural and Veterinarian Sciences Department of Animal Science, Via de Acesso Prof. Paulo Donato Castelane, SP-
Descrição: dc.descriptionUniversity of Jequitinhonha and Mucuri Valleys Department of Animal Science, Rod. MG 367, MG-
Descrição: dc.descriptionUniversity of Viçosa Department of Animal Science, Av. PH Rolfs, MG-
Descrição: dc.descriptionNational Council for Science and Technological Development, DF-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Agricultural and Veterinarian Sciences Department of Animal Science, Via de Acesso Prof. Paulo Donato Castelane, SP-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2017/10630–2-
Descrição: dc.descriptionFAPESP: 2018/20002–6-
Idioma: dc.languageen-
Relação: dc.relationMeat Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBeef cattle-
Palavras-chave: dc.subjectCarcass-
Palavras-chave: dc.subjectGenes-
Palavras-chave: dc.subjectGWAS-
Palavras-chave: dc.subjectMeat quality-
Palavras-chave: dc.subjectNellore cattle-
Título: dc.titleGenome-wide scans identify biological and metabolic pathways regulating carcass and meat quality traits in beef cattle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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