Traditional Use, Chemical Constituents, and Pharmacological Activity of Maytenus elaeodendroides Stem Bark

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Havana-
Autor(es): dc.contributorInstitute of Marine Sciences (ICIMAR)-
Autor(es): dc.contributorUniversidad de Católica del Norte-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Salerno-
Autor(es): dc.contributorNational Biodiversity Future Center-
Autor(es): dc.creatorGarcía, Trina H.-
Autor(es): dc.creatorSpengler, Iraida-
Autor(es): dc.creatorFernández, Antonio-
Autor(es): dc.creatorRodeiro, Idania-
Autor(es): dc.creatorHernández-Balmaseda, Ivones-
Autor(es): dc.creatorCéspedes, Ilianet-
Autor(es): dc.creatorGarrido, Gabino-
Autor(es): dc.creatordos Santos, Lourdes Campaner-
Autor(es): dc.creatorVilegas, Wagner-
Autor(es): dc.creatorCelano, Rita-
Autor(es): dc.creatorD’Elia, Maria-
Data de aceite: dc.date.accessioned2025-08-21T23:10:39Z-
Data de disponibilização: dc.date.available2025-08-21T23:10:39Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/d16110694-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300421-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300421-
Descrição: dc.descriptionPlants belonging to the genus Maytenus are members of the Celastraceae family. They have been widely used by different peoples as treatment for curing many diseases. The aim of this study was to explore the anti-inflammatory and antioxidant properties of Maytenus elaeodendroides stem bark extracts, an endemic Cuban plant. The antioxidant activity of four extracts (EtOH, EtOAc, n-BuOH, and diethyl ether/petroleum ether 1:1) was determined using DPPH and FRAP methods. Meanwhile, anti-inflammatory effects by the edema method were induced by croton oil in the mouse ear. The investigated extracts showed radical reduction capacity and prevented ear inflammation at doses of 4 mg/ear. In addition, FIA/ESI/IT/MSn was used to determine the qualitative chemical composition of the EtOAc extract and allowed the identification of five flavan-3-ol monomers, four dimers, and other proanthocyanidin oligomers. From this extract three flavan-3-ol compounds (elaeocyanidin and 4′-O-methylgallocatechin), one of them new (2′-hydroxy-4′-methoxy-epigallocatechin), and a proanthocyanidin dimer (afzelechin-((Formula presented.))-4′-O-methylepigallocatechin) were isolated and identified by the chromatographic method and spectroscopic techniques, mainly ESI-MS and NMR spectroscopic methods.-
Descrição: dc.descriptionCenter for Natural Product Research Faculty of Chemistry University of Havana-
Descrição: dc.descriptionPharmacology Department Institute of Marine Sciences (ICIMAR), Loma 14, Alturas del Vedado, Plaza de la Revolución-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences Faculty of Sciences Universidad de Católica del Norte, Angamos 0610-
Descrição: dc.descriptionDepartment of Organic Chemistry Institute of Chemistry UNESP—Sao Paulo State University, Araraquara-
Descrição: dc.descriptionExperimental Campus of Sao Vicente UNESP—Sao Paulo State University, Sao Paulo-
Descrição: dc.descriptionDipartimento di Farmacia University of Salerno-
Descrição: dc.descriptionNBFC National Biodiversity Future Center-
Descrição: dc.descriptionDepartment of Organic Chemistry Institute of Chemistry UNESP—Sao Paulo State University, Araraquara-
Descrição: dc.descriptionExperimental Campus of Sao Vicente UNESP—Sao Paulo State University, Sao Paulo-
Idioma: dc.languageen-
Relação: dc.relationDiversity-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject2′-hydroxy-4′-methoxy-epigallocatechin-
Palavras-chave: dc.subjectantioxidant and anti-inflammatory activity-
Palavras-chave: dc.subjectFIA/ESI/IT/MSn-
Palavras-chave: dc.subjectflavan-3-ol-
Palavras-chave: dc.subjectMaytenus elaeodendroides-
Palavras-chave: dc.subjectproanthocyanidins-
Título: dc.titleTraditional Use, Chemical Constituents, and Pharmacological Activity of Maytenus elaeodendroides Stem Bark-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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