Effective Mosquito Repellents: Myrcene- and Cymene-Loaded Nanohydrogels against Aedes aegypti

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal do Amapá-
Autor(es): dc.contributorMIVEGEC-
Autor(es): dc.creatorDuarte, Jonatas Lobato-
Autor(es): dc.creatorDi Filippo, Leonardo Delello-
Autor(es): dc.creatorRibeiro, Tais de Cássia-
Autor(es): dc.creatorSilva, Ana Carolina de Jesus-
Autor(es): dc.creatorHage-Melim, Lorane Izabel da Silva-
Autor(es): dc.creatorDuchon, Stéphane-
Autor(es): dc.creatorCarrasco, David-
Autor(es): dc.creatorPinto, Mara Cristina-
Autor(es): dc.creatorCorbel, Vincent-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T18:06:04Z-
Data de disponibilização: dc.date.available2025-08-21T18:06:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics16081096-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300394-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300394-
Descrição: dc.descriptionAedes mosquito-borne diseases remain a significant global health threat, necessitating effective control strategies. This study introduces monoterpenes-based nanohydrogels for potential use as repellents against Aedes aegypti, the primary dengue vector worldwide. We formulated hydrogels using cymene- and myrcene-based nanoemulsions with different polymers: chitosan, carboxymethylcellulose (CMC), and carbopol®. Our evaluations of rheological, texture, and bioadhesive properties identified CMC hydrogel as the most promising gelling agent for topical application, exhibiting sustained monoterpene release over 12 h with low skin permeation and high retention in the stratum corneum. Myrcene-loaded CMC hydrogel achieved a 57% feeding deterrence compared to 47% with cymene hydrogel in the mosquito membrane-feeding model. Molecular docking studies revealed interactions between myrcene and an essential amino acid (Ile116) in the Ae. aegypti odorant-binding protein 22 (AeOBP22), corroborating its higher repellent efficacy. These findings suggest that myrcene-loaded CMC hydrogels offer a promising, minimally invasive strategy for personal protection against Ae. aegypti and warrant further investigation to optimize monoterpene concentrations for vector control.-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartamento de Ciências Biológicas e da Saúde Universidade Federal do Amapá, Amapá-
Descrição: dc.descriptionIRD CNRS University of Montpellier MIVEGEC-
Descrição: dc.descriptionDepartamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista “Júlio de Mesquita Filho”, São Paulo-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista “Júlio de Mesquita Filho”, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationPharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectarboviruses-
Palavras-chave: dc.subjectcarboxymethylcellulose-
Palavras-chave: dc.subjectcymene-
Palavras-chave: dc.subjectmyrcene-
Palavras-chave: dc.subjectnanoemulsion-
Título: dc.titleEffective Mosquito Repellents: Myrcene- and Cymene-Loaded Nanohydrogels against Aedes aegypti-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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