Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a model

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorHarvard University-
Autor(es): dc.creatorAlves, Samuel de Mattos-
Autor(es): dc.creatorLisboa-Filho, Paulo Noronha-
Autor(es): dc.creatorZilli Vieira, Carolina Letícia-
Autor(es): dc.creatorPiacenti-Silva, Marina-
Data de aceite: dc.date.accessioned2025-08-21T16:19:03Z-
Data de disponibilização: dc.date.available2025-08-21T16:19:03Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fnins.2025.1543826-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300346-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300346-
Descrição: dc.descriptionResearch indicates that by 2050, more than 150 million people will be living with Alzheimer's disease (AD), a condition associated with neurodegeneration due to the accumulation of amyloid-beta and tau proteins. In addition to genetic background, endocrine disruption, and cellular senescence, management of the gut microbiota has emerged as a key element in the diagnosis, progression, and treatment of AD, as certain bacterial metabolites can travel through the bloodstream and cross the blood-brain barrier. This mini-review explores the relationship between tau protein accumulation and gut dysbiosis in Drosophila melanogaster. This model facilitates the investigation of how gut-derived metabolites contribute to neurocognitive impairment and dementia. Understanding the role of direct and indirect bacterial by-products, such as lactate and acetate, in glial cell activation and tau protein dynamics may provide insights into the mechanisms of AD progression and contribute to more effective treatments. Here we discuss how the simplicity and extensive genetic tools of Drosophila make it a valuable model for studying these interactions and testing potential therapeutics, including probiotics. Integrating Drosophila studies with other established models may reveal conserved pathways and accelerate the translation of findings into clinical applications.-
Descrição: dc.descriptionInstitute of Biosciences of Botucatu Campus Botucatu São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Sciences Campus Bauru São Paulo State University (UNESP), SP-
Descrição: dc.descriptionHarvard T. Chan School of Public Health Harvard University-
Descrição: dc.descriptionInstitute of Biosciences of Botucatu Campus Botucatu São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Sciences Campus Bauru São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Neuroscience-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlzheimer's disease-
Palavras-chave: dc.subjectDrosophila melanogaster-
Palavras-chave: dc.subjectgut-brain axis-
Palavras-chave: dc.subjectmicrobiota-
Palavras-chave: dc.subjectneurodegeneration-
Título: dc.titleAlzheimer's disease and gut-brain axis: Drosophila melanogaster as a model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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