Revealing the beneficial effects of a dairy infant formula on the gut microbiota of early childhood children with autistic spectrum disorder using static and SHIME® fermentation models

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Autor(es): dc.contributorUniversidade Federal da Paraíba (UFPB)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal Institute of Sertão de Pernambuco-
Autor(es): dc.contributorUniversidad de Antioquia (UdeA)-
Autor(es): dc.contributorFaculty of Chemical Engineering-
Autor(es): dc.creatorGomes de Oliveira, Louise Iara-
Autor(es): dc.creatorClementino, Jéssika Rodrigues-
Autor(es): dc.creatorSalgaço, Mateus Kawata-
Autor(es): dc.creatorde Oliveira, Sônia Paula Alexandrino-
Autor(es): dc.creatordos Santos Lima, Marcos-
Autor(es): dc.creatorMesa, Victoria-
Autor(es): dc.creatorde Souza, Evandro Leite-
Autor(es): dc.creatorVinderola, Celso Gabriel-
Autor(es): dc.creatorMagnani, Marciane-
Autor(es): dc.creatorSivieri, Katia-
Data de aceite: dc.date.accessioned2025-08-21T21:47:11Z-
Data de disponibilização: dc.date.available2025-08-21T21:47:11Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1039/d3fo01156a-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300339-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300339-
Descrição: dc.descriptionThis study evaluated the impact of the Milnutri Profutura® (MNP) dairy infant formula on the gut microbiota of early childhood children (three to five years) with Autistic Spectrum Disorder (ASD) using static fermentation (time zero, 24, and 48 h) and the Simulator of the Human Intestinal Microbiol Ecosystem (SHIME®) (time zero, 72 h, and 7 days). The relative abundance of selected intestinal bacterial groups, pH values, organic acids, and sugars were verified at time zero, 24, and 48 h using flow cytometry and measurements. In addition, the diversity and changes in the gut microbiota, and the amounts of acetic, butyric, and propionic acids and ammonium ions (NH4+) in fermentation using the SHIME® were measured at time zero, 72 h, and 7 days. MNP increased Lactobacillus/Enterococcus and Bifidobacterium populations and decreased Bacteroides/Prevotella, Clostridium histolyticum and Eubacterium rectale/Clostridium coccoides populations (p < 0.05) at 24 and 48 h of static fermentation, showing a positive prebiotic activity score (65.18 ± 0.07). The pH, fructose and glucose decreased, while lactic, butyric, and propionic acids increased (p < 0.05) at 48 h of static fermentation. MNP increased (p < 0.05) the Firmicutes phylum during the fermentation in SHIME®. MNP decreased the diversity at 72 h of fermentation, mostly by the increase (p < 0.05) in the Lactobacillus genus. Microbial groups considered harmful such as Lachnospiraceae, Negativicoccus, and Lachnoclostridium were inhibited after administration with MNP. Propionic and butyric acids increased at 72 h and NH4+ decreased (p < 0.05) at the end of fermentation with MNP. The results indicate MNP as an infant formula which may benefit the gut microbiota of children with ASD.-
Descrição: dc.descriptionPost-Graduate Program in Nutritional Sciences Health Sciences Center Federal University of Paraíba (Universidade Federal da Paraíba - UFPB)-
Descrição: dc.descriptionDepartment of Food and Nutrition Laboratory of Food Microbiology School of Pharmaceutical Sciences São Paulo State University-
Descrição: dc.descriptionDepartment of Food Technology Federal Institute of Sertão de Pernambuco, Campus Petrolina-
Descrição: dc.descriptionFood and Human Nutrition Research Group School of Nutrition and Dietetics Universidad de Antioquia (UdeA)-
Descrição: dc.descriptionDepartment of Biotechnology and Food Technology Faculty of Chemical Engineering, Universidad Nacional del Litoral-
Descrição: dc.descriptionDepartment of Food and Nutrition Laboratory of Food Microbiology School of Pharmaceutical Sciences São Paulo State University-
Formato: dc.format8964-8974-
Idioma: dc.languageen-
Relação: dc.relationFood and Function-
???dc.source???: dc.sourceScopus-
Título: dc.titleRevealing the beneficial effects of a dairy infant formula on the gut microbiota of early childhood children with autistic spectrum disorder using static and SHIME® fermentation models-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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