Novel highly flexible collagen-loaded latex dressing to treat diabetic foot ulcer: A pilot clinical trial

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Autor(es): dc.contributorTerasaki Institute for Biomedical Innovation-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Ribeirão Preto (UNAERP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorPontificia Universidad Católica de Valparaíso-
Autor(es): dc.contributorImperial College London-
Autor(es): dc.contributorFundação Educacional do Município de Assis (FEMA)-
Autor(es): dc.contributorUniversity Hospital Ghent-
Autor(es): dc.contributorCalifornia State University-
Autor(es): dc.contributorFederal University of Triângulo Mineiro (UFTM)-
Autor(es): dc.contributorUndergraduate Course in Nursing-
Autor(es): dc.contributorNational Center of Research in Energy and Materials (CNPEM)-
Autor(es): dc.creatorde Barros, Natan Roberto-
Autor(es): dc.creatorChagas, Ana Laura Destro-
Autor(es): dc.creatorForster, Samuel-
Autor(es): dc.creatorSant'Ana Pegorin Brasil, Giovana-
Autor(es): dc.creatorRibeiro, Geraldo Monteiro-
Autor(es): dc.creatorOlivato, Orestes Pereira-
Autor(es): dc.creatorRamalho, Leandra Náira Zambelli-
Autor(es): dc.creatorGuerra, Nayrim Brizuela-
Autor(es): dc.creatorMussagy, Cassamo Ussemane-
Autor(es): dc.creatorFloriano, Juliana Ferreira-
Autor(es): dc.creatorBarbosa, Angélica Mércia Pascon-
Autor(es): dc.creatorRudge, Marilza Vieira Cunha-
Autor(es): dc.creatorSilva, Rosângela Gonçalves-
Autor(es): dc.creatorFarhadi, Neda-
Autor(es): dc.creatorMohaghegh, Neda-
Autor(es): dc.creatorMonirizad, Mahsa-
Autor(es): dc.creatorPeirsman, Arne-
Autor(es): dc.creatorGomez, Alejandro-
Autor(es): dc.creatorde Mendonça, Ricardo José-
Autor(es): dc.creatordos Santos, Lindomar Soares-
Autor(es): dc.creatorMarcaccini, Andrea Marcia-
Autor(es): dc.creatorTognoli, Silvia-
Autor(es): dc.creatorBinotto, Cibele Correia S.-
Autor(es): dc.creatorDomingues, Aline Natalia-
Autor(es): dc.creatorJucaud, Vadim-
Autor(es): dc.creatorMendes, Adriana Aparecida-
Autor(es): dc.creatorOliveira, Amanda Santos-
Autor(es): dc.creatorLi, Bingbing-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Data de aceite: dc.date.accessioned2025-08-21T20:38:41Z-
Data de disponibilização: dc.date.available2025-08-21T20:38:41Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2025.142615-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300287-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300287-
Descrição: dc.descriptionDiabetic Foot Ulcers (DFUs) are a common and severe complication of long-term, poorly managed type 2 diabetes. Among the 537 million people worldwide with type 2 diabetes, 19 % to 34 % are expected to develop a DFU in their lifetime. As life expectancy increases, so does the prevalence of DFUs, leading to complex and costly long-term care. This study introduces a novel, flexible dressing composed of natural rubber latex (NRL) infused with collagen (NRL-C), leveraging the natural healing properties of these biomaterials. The efficacy of NRL-C was validated through physicochemical characterization, in vitro and in vivo studies, and a pilot clinical trial. Results demonstrated that the NRL-C dressing promotes angiogenesis in endothelial cells, stimulates fibroblast and keratinocyte proliferation, accelerates wound closure, and exhibits biocompatibility in rodent models. Additionally, a pilot clinical study involving six diabetic patients revealed promising therapeutic outcomes, highlighting the potential of NRL-C as a cost-effective, safe, and sustainable strategy for DFU treatment.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionTerasaki Institute for Biomedical Innovation, 11507 W Olympic Blvd-
Descrição: dc.descriptionBioengineering and Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), 55 Francisco Degni Prof.-
Descrição: dc.descriptionSchool of Dentistry University of Ribeirão Preto (UNAERP), SP-
Descrição: dc.descriptionDepartment of Pathology Ribeirão Preto Medical School University of São Paulo (USP)-
Descrição: dc.descriptionSchool of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionEscuela de Agronomía Facultad de Ciencias Agronómicas y de los Alimentos Pontificia Universidad Católica de Valparaíso-
Descrição: dc.descriptionNational Heart and Lung Institute Imperial College London, Translational and Experimental Medicine Building, 3rd floor, Du Cane Road-
Descrição: dc.descriptionFundação Educacional do Município de Assis (FEMA)-
Descrição: dc.descriptionPlastic Reconstructive and Aesthetic Surgery University Hospital Ghent-
Descrição: dc.descriptionAutonomy Research Center for STEAHM (ARCS) California State University-
Descrição: dc.descriptionDepartment of Biochemistry Pharmacology and Physiology Federal University of Triângulo Mineiro (UFTM)-
Descrição: dc.descriptionUniversity of Araraquara (UNIARA) Undergraduate Course in Nursing, 1338 Carlos Gomes Street-
Descrição: dc.descriptionFaculty of Philosophy Sciences and Languages of Ribeirão Preto São Paulo University (USP), 3900 Bandeirantes Avenue-
Descrição: dc.descriptionNational Laboratory of Bioscience (LNBio) National Center of Research in Energy and Materials (CNPEM)-
Descrição: dc.descriptionBioengineering and Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), 55 Francisco Degni Prof.-
Descrição: dc.descriptionSchool of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2011/17411-8-
Descrição: dc.descriptionFAPESP: 2017/02518-8-
Descrição: dc.descriptionFAPESP: 2017/19603-8-
Descrição: dc.descriptionFAPESP: 2018/07342-8-
Descrição: dc.descriptionFAPESP: 2023/17448-6-
Descrição: dc.descriptionCNPq: 317203/2021- 5-
Descrição: dc.descriptionCNPq: 401285/2022-7-
Descrição: dc.descriptionCNPq: 470261/2012-9-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCollagen-
Palavras-chave: dc.subjectDiabetic foot ulcers-
Palavras-chave: dc.subjectNatural rubber latex-
Palavras-chave: dc.subjectPilot clinical study-
Palavras-chave: dc.subjectRegenerative medicine-
Palavras-chave: dc.subjectWound healing-
Título: dc.titleNovel highly flexible collagen-loaded latex dressing to treat diabetic foot ulcer: A pilot clinical trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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