Epidemiological, clinical, and genomic landscape of coccidioidomycosis in northeastern Brazil

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Autor(es): dc.contributorFederal University of Piauí-UFPI-
Autor(es): dc.contributorNorthern Arizona University-
Autor(es): dc.contributorFiocruz - RJ-
Autor(es): dc.contributorUniversity of Brasília-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUC-Davis-
Autor(es): dc.contributorCentre hospitalier de Cayenne – French Guiana-
Autor(es): dc.contributorUniversidade Católica de Brasília-
Autor(es): dc.creatorEulálio, Kelsen Dantas-
Autor(es): dc.creatorKollath, Daniel R.-
Autor(es): dc.creatorMartins, Liline Maria Soares-
Autor(es): dc.creatorFilho, Antonio de Deus-
Autor(es): dc.creatorCavalcanti, Maria do Amparo Salmito-
Autor(es): dc.creatorMoreira, Lucas Machado-
Autor(es): dc.creatorTenório, Bernardo Guerra-
Autor(es): dc.creatorAlves, Lucas Gomes de Brito-
Autor(es): dc.creatorYamauchi, Danielle-
Autor(es): dc.creatorBarrozo, Ligia Vizeu-
Autor(es): dc.creatorThompson III, George R.-
Autor(es): dc.creatorNacher, Mathieu-
Autor(es): dc.creatorStajich, Jason E.-
Autor(es): dc.creatorBenard, Gil-
Autor(es): dc.creatorBagagli, Eduardo-
Autor(es): dc.creatorFelipe, Maria Sueli Soares-
Autor(es): dc.creatorBarker, Bridget M.-
Autor(es): dc.creatorTrilles, Luciana-
Autor(es): dc.creatorTeixeira, Marcus de Melo-
Data de aceite: dc.date.accessioned2025-08-21T16:18:00Z-
Data de disponibilização: dc.date.available2025-08-21T16:18:00Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41467-024-47388-0-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300226-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300226-
Descrição: dc.descriptionCoccidioidomycosis, listed as a priority mycosis by the WHO, is endemic in the United States but often overlooked in Central and South America. Employing a multi-institutional approach, we investigate how disease characteristics, pathogen genetic variation, and environmental factors impact coccidioidomycosis epidemiology and outcomes in South America. We identified 292 cases (1978–2021) and 42 outbreaks in Piauí and Maranhão states, Brazil, the largest series outside the US/Mexico epidemic zone. The male-to-female ratio was 57.4:1 and the most common activity was armadillo hunting (91.1%) 4 to 30 days before symptom onset. Most patients (92.8%) exhibited typical acute pulmonary disease, with cough (93%), fever (90%), and chest pain (77%) as predominant symptoms. The case fatality rate was 8%. Our negative binomial regression model indicates that reduced precipitation levels in the current (p = 0.015) and preceding year (p = 0.001) predict heightened incidence. Unlike other hotspots, acidic soil characterizes this region. Brazilian strains differ genomically from other C. posadasii lineages. Northeastern Brazil presents a distinctive coccidioidomycosis profile, with armadillo hunters facing elevated risks. Low annual rainfall emerges as a key factor in increasing cases. A unique C. posadasii lineage in Brazil suggests potential differences in environmental, virulence, and/or pathogenesis traits compared to other Coccidioides genotypes.-
Descrição: dc.descriptionHospital de Doenças Infecto Contagiosas-HDIC Federal University of Piauí-UFPI, Piauí-
Descrição: dc.descriptionThe Pathogen and Microbiome Institute Northern Arizona University-
Descrição: dc.descriptionEvandro Chagas National Institute of Infectology Fiocruz - RJ-
Descrição: dc.descriptionFaculty of Medicine University of Brasília, Federal District-
Descrição: dc.descriptionDepartamento de Microbiologia e Imunologia Instituto de Biociências de Botucatu Universidade Estadual Paulista/UNESP-
Descrição: dc.descriptionDepartment of Geography Faculty of Philosophy Languages and Literature and Human Sciences University of São Paulo-
Descrição: dc.descriptionDepartment of Internal Medicine Division of Infectious Diseases and Department of Medical Microbiology and Immunology UC-Davis-
Descrição: dc.descriptionCentre d’Investigations Cliniques INSERM 1424 Centre hospitalier de Cayenne – French Guiana-
Descrição: dc.descriptionDepartment of Microbiology and Plant Pathology University of California-Riverside-
Descrição: dc.descriptionLaboratório de Micologia Medica Departamento de Dermatologia Instituto de Medicina Tropical Faculdade de Medicina University of São Paulo-
Descrição: dc.descriptionUniversidade Católica de Brasília-
Descrição: dc.descriptionDepartamento de Microbiologia e Imunologia Instituto de Biociências de Botucatu Universidade Estadual Paulista/UNESP-
Idioma: dc.languageen-
Relação: dc.relationNature Communications-
???dc.source???: dc.sourceScopus-
Título: dc.titleEpidemiological, clinical, and genomic landscape of coccidioidomycosis in northeastern Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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