Use of Phosphodiesterase Inhibitors in the Postoperative Period of Skin Flaps: A Systematic Review

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDaronch, Oona Tomiê-
Autor(es): dc.creatorMarcante, Renata Fernanda Ramos-
Autor(es): dc.creatorNeto, Aristides Augusto Palhares-
Autor(es): dc.creatorViterbo, Fausto-
Data de aceite: dc.date.accessioned2025-08-21T15:52:40Z-
Data de disponibilização: dc.date.available2025-08-21T15:52:40Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-06-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1097/GOX.0000000000004978-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300192-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300192-
Descrição: dc.descriptionBackground: Ischemia-reperfusion injury can occur in several clinical conditions, and it has been widely studied in the context of skin flaps. Vascular distress results in an imbalance between the supply and demand of oxygen to living tissues, and the result of this process is tissue necrosis. Several drugs have been studied to reduce vascular distress of skin flaps and tissue loss. Methods: The present study performed a systematic review of literature in the main databases (PubMed, Web of Science, LILACS, SciELO, and Cochrane), including articles published in the last 10 years. Results: It was observed that phosphodiesterase inhibitors, mainly types III and V, have shown promising results in terms of vascularization of the postoperative skin flap, especially when started on the first postoperative day and maintained for 7 days. Conclusion: New studies with different posology, duration of use, and new drugs are needed to better elucidate the use of this substance to optimize the circulation of skin flaps.-
Descrição: dc.descriptionThe Plastic Surgery Department Faculty of Medicine of Botucatu State University of São Paulo (UNESP) University Hospital-
Descrição: dc.descriptionThe Plastic Surgery Department Faculty of Medicine of Botucatu State University of São Paulo (UNESP) University Hospital-
Formato: dc.formatE4978-
Idioma: dc.languageen-
Relação: dc.relationPlastic and Reconstructive Surgery - Global Open-
???dc.source???: dc.sourceScopus-
Título: dc.titleUse of Phosphodiesterase Inhibitors in the Postoperative Period of Skin Flaps: A Systematic Review-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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