Activity of Bacteriophage D29 Loaded on Nanoliposomes against Macrophages Infected with Mycobacterium tuberculosis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad Católica de Santa María-
Autor(es): dc.contributorUniversity of Brasilia (UNB)-
Autor(es): dc.contributorNational Institute of Health (NIH)-
Autor(es): dc.creatorSilva, Ana P. B.-
Autor(es): dc.creatorRoque-Borda, Cesar Augusto-
Autor(es): dc.creatorCarnero Canales, Christian S.-
Autor(es): dc.creatorDuran Gleriani Primo, Laura Maria-
Autor(es): dc.creatorSilva, Isabel C.-
Autor(es): dc.creatorRibeiro, Camila M.-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorda Silva, Patrícia Bento-
Autor(es): dc.creatorSilva, Joás L.-
Autor(es): dc.creatorPavan, Fernando Rogério-
Data de aceite: dc.date.accessioned2025-08-21T23:04:43Z-
Data de disponibilização: dc.date.available2025-08-21T23:04:43Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/diseases11040150-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300155-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300155-
Descrição: dc.descriptionThe search for new antimicrobial agents is a continuous struggle, mainly because more and more cases of resistant strains are being reported. Mycobacterium tuberculosis (MTB) is the main microorganism responsible for millions of deaths worldwide. The development of new antimicrobial agents is generally aimed at finding strong interactions with one or more bacterial receptors. It has been proven that bacteriophages have the ability to adhere to specific and selective regions. However, their transport and administration must be carefully evaluated as an excess could prevent a positive response and the bacteriophages may be eliminated during their journey. With this in mind, the mycobacteriophage D29 was encapsulated in nanoliposomes, which made it possible to determine its antimicrobial activity during transport and its stability in the treatment of active and latent Mycobacterium tuberculosis. The antimicrobial activity, the cytotoxicity in macrophages and fibroblasts, as well as their infection and time–kill were evaluated. Phage nanoencapsulation showed efficient cell internalization to induce MTB clearance with values greater than 90%. Therefore, it was shown that nanotechnology is capable of assisting in the activity of degradation-sensitive compounds to achieve better therapy and evade the immune response against phages during treatment.-
Descrição: dc.descriptionTuberculosis Research Laboratory School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFacultad de Ciencias Farmaceuticas Bioquímicas y Biotecnológicas Universidad Católica de Santa María-
Descrição: dc.descriptionDepartment of Genetics and Morphology of the Institute of Biological Sciences University of Brasilia (UNB)-
Descrição: dc.descriptionNational Heart Lung and Blood Institute National Institute of Health (NIH)-
Descrição: dc.descriptionTuberculosis Research Laboratory School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationDiseases-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectintracellular activity-
Palavras-chave: dc.subjectliposome-
Palavras-chave: dc.subjectmycobacteriophage D29-
Palavras-chave: dc.subjectMycobacterium tuberculosis-
Título: dc.titleActivity of Bacteriophage D29 Loaded on Nanoliposomes against Macrophages Infected with Mycobacterium tuberculosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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