Ozone therapy effect in medication-related osteonecrosis of the jaw as prevention or treatment: microtomographic, confocal laser microscopy and histomorphometric analysis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Brasília (UnB)-
Autor(es): dc.contributorLouisiana State University Health Sciences Center (LSU)-
Autor(es): dc.creatorPereira-Silva, Maísa-
Autor(es): dc.creatorHadad, Henrique-
Autor(es): dc.creatorde Jesus, Laís Kawamata-
Autor(es): dc.creatorde Freitas Santana Oliveira, Maria Eduarda-
Autor(es): dc.creatorde Almeida, Juliano Milanezi-
Autor(es): dc.creatorNímia, Heloisa Helena-
Autor(es): dc.creatorMagro Filho, Osvaldo-
Autor(es): dc.creatorOkamoto, Roberta-
Autor(es): dc.creatorMacedo, Sérgio Bruzadelli-
Autor(es): dc.creatorPalmieri Junior, Celso Fernando-
Autor(es): dc.creatorSouza, Francisley Ávila-
Data de aceite: dc.date.accessioned2025-08-21T17:01:43Z-
Data de disponibilização: dc.date.available2025-08-21T17:01:43Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-024-05547-z-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300150-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300150-
Descrição: dc.descriptionObjective: This study aimed to evaluate the efficacy of ozone therapy in the preoperative (prevention) and/or postoperative (treatment) of MRONJ. Material and methods: Forty male Wistar rats were caudally treated with zoledronic acid (ZOL) and to ozone therapy before extraction (prevention, POG), after extraction (treatment, TOG), or both (prevention and treatment, TPOG), and treated with saline (SAL). The animals received intramuscular fluorochrome (calcein and alizarin), and 28 days postoperatively, they were euthanized, and the tissues were subjected to microtomographic computed tomography (microCT), LASER confocal, and histomorphometric analyses. Results: Micro-CT showed a higher bone volume fraction average in all groups than that in the ZOL group (P < 0.001), the ZOL group showed high porosity (P = 0.03), and trabecular separation was greater in the TOG group than in the POG group (P < 0.05). The mineral apposition rate of the POG group was high (20.46 ± 6.31) (P < 0.001), followed by the TOG group (20.32 ± 7.4). The TOG group presented the highest mean newly formed bone area (68.322 ± 25.296) compared with the ZOL group (P < 0.05), followed by the SAL group (66.039 ± 28.379) and ZOL groups (60.856 ± 28.425). Conclusions: Ozone therapy modulated alveolar bone repair in animals treated with ZOL, mainly after surgery trauma, leading to bone formation as healing tissue. Clinical relevance: Osteonecrosis has been a challenge in dentistry, and owing to the lack of a consensus regarding therapy, studies presenting new therapies are important, and ozone has been one of the therapies explored empirically.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araçatuba Dental School São Paulo State University (UNESP), José Bonifácio Street, 1193, Vila Mendonça, Araçatuba-
Descrição: dc.descriptionDepartment of Dental Materials and Prothesis Araçatuba Dental School São Paulo State University (UNESP), José Bonifácio Street, Araçatuba-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba Dental School São Paulo State University (UNESP), Marechal Rondon Highway, Araçatuba-
Descrição: dc.descriptionDepartment of Dentistry University of Brasília (UnB), Asa Norte, Distrito Federal-
Descrição: dc.descriptionDepartment of Oral & amp; Maxillofacial Surgery Louisiana State University Health Sciences Center (LSU), Kings Highway-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araçatuba Dental School São Paulo State University (UNESP), José Bonifácio Street, 1193, Vila Mendonça, Araçatuba-
Descrição: dc.descriptionDepartment of Dental Materials and Prothesis Araçatuba Dental School São Paulo State University (UNESP), José Bonifácio Street, Araçatuba-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba Dental School São Paulo State University (UNESP), Marechal Rondon Highway, Araçatuba-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBisphosphonates-
Palavras-chave: dc.subjectDental alveolus-
Palavras-chave: dc.subjectOsteonecrosis-
Palavras-chave: dc.subjectOzone-
Título: dc.titleOzone therapy effect in medication-related osteonecrosis of the jaw as prevention or treatment: microtomographic, confocal laser microscopy and histomorphometric analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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