Photochemical outcomes triggered by gold shell-isolated nanorods on bioinspired nanoarchitectonics for bacterial membranes

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorAlmeida, Alexandre M.-
Autor(es): dc.creatorMoreira, Lucas G.-
Autor(es): dc.creatorCamacho, Sabrina A.-
Autor(es): dc.creatorFerreira, Fabiana G.-
Autor(es): dc.creatorConceição, Katia-
Autor(es): dc.creatorTada, Dayane B.-
Autor(es): dc.creatorAoki, Pedro H.B.-
Data de aceite: dc.date.accessioned2025-08-21T16:59:29Z-
Data de disponibilização: dc.date.available2025-08-21T16:59:29Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbamem.2023.184216-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300134-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300134-
Descrição: dc.descriptionBoosted by the indiscriminate use of antibiotics, multidrug-resistance (MDR) demands new strategies to combat bacterial infections, such as photothermal therapy (PTT) based on plasmonic nanostructures. PTT efficiency relies on photoinduced damage caused to the bacterial machinery, for which nanostructure incorporation into the cell envelope is key. Herein, we shall unveil the binding and photochemical mechanisms of gold shell-isolated nanorods (AuSHINRs) on bioinspired bacterial membranes assembled as Langmuir and Langmuir-Schaefer (LS) monolayers of DOPE, Lysyl-PG, DOPG and CL. AuSHINRs incorporation expanded the isotherms, with stronger effect on the anionic DOPG and CL. Indeed, FTIR of LS films revealed more modifications for DOPG and CL owing to stronger attractive electrostatic interactions between anionic phosphates and the positively charged AuSHINRs, while electrostatic repulsions with the cationic ethanolamine (DOPE) and lysyl (Lysyl-PG) polar groups might have weakened their interactions with AuSHINRs. No statistical difference was observed in the surface area of irradiated DOPE and Lysyl-PG monolayers on AuSHINRs, which is evidence of the restricted nanostructures insertion. In contrast, irradiated DOPG monolayer on AuSHINRs decreased 4.0 % in surface area, while irradiated CL monolayer increased 3.7 %. Such results agree with oxidative reactions prompted by ROS generated by AuSHINRs photoactivation. The deepest AuSHINRs insertion into DOPG may have favored chain cleavage while hydroperoxidation is the mostly like outcome in CL, where AuSHINRs are surrounding the polar groups. Furthermore, preliminary experiments on Escherichia coli culture demonstrated that the electrostatic interactions with AuSHINRs do not inhibit bacterial growth, but the photoinduced effects are highly toxic, resulting in microbial inactivation.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Sciences Humanities and Languages, SP-
Descrição: dc.descriptionIFSC São Carlos Institute of Physics University of São Paulo (USP), SP-
Descrição: dc.descriptionInstitute of Science and Technology Federal University of São Paulo (UNIFESP), SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Sciences Humanities and Languages, SP-
Descrição: dc.descriptionFAPESP: 2018/14692-5-
Descrição: dc.descriptionFAPESP: 2018/22214-6-
Descrição: dc.descriptionFAPESP: 2020/15854-9-
Descrição: dc.descriptionFAPESP: 2022/02189-2-
Idioma: dc.languageen-
Relação: dc.relationBiochimica et Biophysica Acta - Biomembranes-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBioinspired bacterial membranes-
Palavras-chave: dc.subjectGold shell-isolated nanorods (AuSHINRs)-
Palavras-chave: dc.subjectPhotothermal therapy-
Título: dc.titlePhotochemical outcomes triggered by gold shell-isolated nanorods on bioinspired nanoarchitectonics for bacterial membranes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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