Postmenopausal women treated for breast cancer with insulin resistance: clinical, analytical, cross-sectional

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Autor(es): dc.contributorUniversidade do Oeste Paulista - UNOESTE-
Autor(es): dc.contributorFederal University of Triangulo Mineiro – UFTM-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorOrsatti, Claudio Lera-
Autor(es): dc.creatorOrsatti, Fabio Lera-
Autor(es): dc.creatorDe Souza, João Pedro Esteves Alves-
Autor(es): dc.creatorde Araujo Brito Buttros, Daniel-
Autor(es): dc.creatorNahas, Eliana Aguiar Petri-
Data de aceite: dc.date.accessioned2025-08-21T17:44:52Z-
Data de disponibilização: dc.date.available2025-08-21T17:44:52Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/03630242.2024.2383289-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300129-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300129-
Descrição: dc.descriptionThis study aims to investigate the potential association between serum levels of cytokines, HSP60, HSP70 and IR (HOMA-IR) in postmenopausal women. We conducted a cross-sectional study involving 381 postmenopausal women, including 94 with a breast cancer diagnosis and 278 without. We analyzed anthropometric and laboratory measurements. Immunoassays were used to measure cytokines (TNF-α, IL-10, and IL-6) as well as heat shock proteins (HSP) 60 and 70 in the serum using the ELISA technique. Women diagnosed with breast cancer showed higher levels of HOMA-IR, IL-6, TNF, and HSP60, and lower levels of IL-10 and HSP70 compared to women without cancer. An association was found between HSP70 and HOMA-IR only in women with breast cancer (β = 0.22, p =.030; without cancer: β = 0.04, p =.404), regardless of age, waist circumference, smoking, and physical activity. No associations were observed between cytokines, HSP60, and HOMA-IR in both groups of women. HSP70 is positively associated with IR in women diagnosed with breast cancer.-
Descrição: dc.descriptionDepartment of Health Sciences Universidade do Oeste Paulista - UNOESTE-
Descrição: dc.descriptionApplied Physiology Nutrition and Exercise Research Group– PhyNEr Institute of Health Sciences Federal University of Triangulo Mineiro – UFTM-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University-UNESP-
Formato: dc.format584-594-
Idioma: dc.languageen-
Relação: dc.relationWomen and Health-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBreast cancer-
Palavras-chave: dc.subjectcardiovascular risk-
Palavras-chave: dc.subjectHOMA-IR-
Palavras-chave: dc.subjectinsulin resistance-
Palavras-chave: dc.subjectpostmenopausal-
Título: dc.titlePostmenopausal women treated for breast cancer with insulin resistance: clinical, analytical, cross-sectional-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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