Adjuvant effects of Saccharomyces cerevisiae in the treatment of experimental periodontitis in rats undergoing chemotherapy

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorInstituto Latino Americano de Pesquisa e Ensino Odontológico (ILAPEO)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGarcia, Valdir Gouveia-
Autor(es): dc.creatorda ROCHA, Tiago Esgalha-
Autor(es): dc.creatorGomes, Natália Amanda-
Autor(es): dc.creatorMiessi, Daniela Maria Janjácomo-
Autor(es): dc.creatorNuernberg, Marta Aparecida Alberton-
Autor(es): dc.creatorRodrigues, João Victor Soares-
Autor(es): dc.creatorCardoso, Jânderson de Medeiros-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorTheodoro, Letícia Helena-
Data de aceite: dc.date.accessioned2025-08-21T16:27:43Z-
Data de disponibilização: dc.date.available2025-08-21T16:27:43Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1678-7757-2023-0135-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300107-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300107-
Descrição: dc.descriptionSurgical procedures, radiotherapy, and chemotherapy, individually or in association, are current oncological treatments. Among the most used chemotherapy drugs, 5-fluorouracil (5FU) is an antimetabolite with a broad spectrum of action. This study evaluated the effects of probiotics (PRO) as an adjuvant to the treatment of experimental periodontitis (EP) in rats immunosuppressed with 5FU. Methodology: 108 rats were randomly allocated to six different groups: EP; SS – systemic treatment with saline solution (SS); 5FU – systemic treatment with 5FU; 5FU+PRO – systemic treatment with 5FU, followed by the local administration of Saccharomyces cerevisiae; 5FU+SRP – systemic treatment with 5-FU, followed by scaling and root planing (SRP); and 5FU+SRP+PRO – systemic treatment with 5FU followed by local treatments with SRP and PRO. Immunosuppression was obtained at two points: at the time of ligature installation and after 48 h. Six animals from each group were euthanized at seven, 15, and 30 d and hemimandibles were collected and processed for histopathological, histometric, and immunohistochemical analysis. Data were subjected to statistical analysis (α=5%). Results: At 7 d, the 5FU+PRO group showed less bone resorption and better structured connective tissue compared with the EP, SS, 5FU+SRP, and 5FU+SRP+PRO groups. At 15 d, the 5FU+SRP group showed a greater intensity of the inflammatory response (p<0.05). At 30 d, the 5FU+SRP+PRO group showed better structured bone tissue and a higher percentage of bone tissue (PBT) than the EP, SS, 5FU, and 5FU+PRO groups (p<0.05). Conclusion: The use of Saccharomyces cerevisiae as monotherapy or as an adjuvant to periodontal therapy may have a positive effect on bone repair in immunosuppressed conditions.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstituto Latino Americano de Pesquisa e Ensino Odontológico (ILAPEO), PR-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Diagnóstico e Cirurgia Divisão Periodontia, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Ciências Básicas, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Diagnóstico e Cirurgia Divisão Periodontia, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Ciências Básicas, SP-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2011/20969-0-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Oral Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnimal model-
Palavras-chave: dc.subjectCancer-
Palavras-chave: dc.subjectChemotherapy-
Palavras-chave: dc.subjectFluorouracil-
Palavras-chave: dc.subjectPeriodontitis-
Palavras-chave: dc.subjectPeriodontology-
Palavras-chave: dc.subjectProbiotics-
Título: dc.titleAdjuvant effects of Saccharomyces cerevisiae in the treatment of experimental periodontitis in rats undergoing chemotherapy-
Tipo de arquivo: dc.typelivro digital-
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