Genotoxicity analysis of a flame retardant, aluminum diethylphosphinate

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Autor(es): dc.contributorFederal Fluminense University-
Autor(es): dc.contributorState University of Rio de Janeiro-
Autor(es): dc.contributorFederal University of the State of Rio de Janeiro-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLeoncio, T. O.L.-
Autor(es): dc.creatorFernandes, A. S.-
Autor(es): dc.creatorFelzenszwalb, I.-
Autor(es): dc.creatorAraujo-Lima, C. F.-
Autor(es): dc.creatorOliveira, D. P.-
Autor(es): dc.creatorDorta, D. J.-
Autor(es): dc.creatorSampaio, C. F.-
Autor(es): dc.creatorFerraz, E. R.A.-
Data de aceite: dc.date.accessioned2025-08-21T16:15:02Z-
Data de disponibilização: dc.date.available2025-08-21T16:15:02Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mrgentox.2024.503829-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300086-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300086-
Descrição: dc.descriptionFlame retardants, crucial for fire prevention, are used worldwide, but they are considered to be ‘emerging contaminants’ and may pose risks to human and environmental health. Aluminum diethyl phosphinate (ALPI) is a halogen-free flame retardant. To evaluate the toxicity of this compound, the following assays were performed: Salmonella/microsome mutagenicity assay; toxicity assays with two endpoints (mitochondrial dehydrogenase activity, plasma membrane integrity); micronucleus assay with human hepatoma cell line HepG2. ALPI was not mutagenic in Salmonella strains TA97, TA98, TA100, TA102, or TA104. ALPI was not cytotoxic at any concentration tested. The HepG2 micronucleus assay showed genotoxicity of ALPI at 200 µg/mL and no cytotoxicity (cytokinesis-block proliferation index, CBPI). Our data are relevant to the regulation of flame retardants.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSchool of Pharmacy Federal Fluminense University, RJ-
Descrição: dc.descriptionDepartment of Biophysics and Biometrics Roberto Alcantara Gomes Biology Institute State University of Rio de Janeiro-
Descrição: dc.descriptionDepartment of Genetics and Molecular Biology Federal University of the State of Rio de Janeiro-
Descrição: dc.descriptionUniversity of São Paulo Ribeirão Preto, SP-
Descrição: dc.descriptionNational Institute for Alternative Technologies for the Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) UNESP Institute of Chemistry, SP-
Descrição: dc.descriptionNational Institute for Alternative Technologies for the Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) UNESP Institute of Chemistry, SP-
Descrição: dc.descriptionCNPq: 302345/2017-5-
Idioma: dc.languageen-
Relação: dc.relationMutation Research - Genetic Toxicology and Environmental Mutagenesis-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEmerging contaminants-
Palavras-chave: dc.subjectIn vitro assays-
Palavras-chave: dc.subjectToxicity-
Título: dc.titleGenotoxicity analysis of a flame retardant, aluminum diethylphosphinate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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