Iron metabolism disorders of patients with chronic paracoccidioidomycosis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Mato Grosso do Sul-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorda Costa Alvarenga de Brito, Eliana-
Autor(es): dc.creatorSiqueira, Igor Valadares-
Autor(es): dc.creatorVenturini, James-
Autor(es): dc.creatorFélix, Vinícius Lopes Teodoro-
Autor(es): dc.creatordos Santos, Alana Oswaldina Gavioli Meira-
Autor(es): dc.creatorMendes, Rinaldo Poncio-
Autor(es): dc.creatorWeber, Simone Schneider-
Autor(es): dc.creatorPaniago, Anamaria Mello Miranda-
Data de aceite: dc.date.accessioned2025-08-21T16:34:12Z-
Data de disponibilização: dc.date.available2025-08-21T16:34:12Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0282218-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300063-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300063-
Descrição: dc.descriptionParacoccidioidomycosis (PCM) is caused by Paracoccidioides spp.; during infection, some host mechanisms limit the availability of iron, thereby reducing its reproduction. However, Paracoccidioides spp. can evade the immune defense and, even under limited iron conditions, use this mineral for growth and dissemination. This study evaluated the iron metabolism of 39 patients who were diagnosed with chronic PCM from 2013 to 2021. The forms of iron before treatment and at the time of clinical cure were evaluated based on the following: serum ferritin levels (storage iron); total iron-binding capacity (TIBC) and transferrin saturation (TSAT) level (transport iron); red blood cell (RBC), hemoglobin (Hb), hematocrit (HCT), and soluble transferrin receptor (sTfR) levels; and sTfR/log ferritin ratio (functional iron). The mean age of the patients was 54.5 years (±6.7 years). Most patients were men (97.4%), rural workers (92.1%), and smokers (84.6%); furthermore, most had moderate disease severity (66.7%). After achieving clinical cure, we observed that serum ferritin levels decreased, and parameters of functional iron increased. The extent of alteration in these parameters were more pronounced in severe cases than in to mild or moderate cases. Furthermore, moderate correlations were observed between C-reactive protein and the Hb (r = -0.500; p = 0.002), RBC (r = -0.461; p = 0.005), HCT (r = -0.514; p = 0.001), and iron levels (r = -0.491; p = 0.002). However, it is possible to infer that PCM interferes with functional and storage iron because improvements in these parameters after treatment as well as associations with disease severity were observed. PCM can lead to anemia of inflammation, which can be differentiated from iron deficiency anemia by a careful investigation of the iron form parameters.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionGraduate Program in Infectious and Parasitic Diseases Faculty of Medicine Federal University of Mato Grosso do Sul, Mato Grosso do Sul-
Descrição: dc.descriptionScientific Initiation CNPq Faculty of Medicine Federal University of Mato Grosso do Sul, Mato Grosso do Sul-
Descrição: dc.descriptionGraduate Program in Health and Development of the Central West Region Federal University of Mato Grosso do Sul, Mato Grosso do Sul-
Descrição: dc.descriptionDepartment of Tropical Diseases Botucatu Medical School Universidade Estadual Paulista (UNESP), Botucatu-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences Food and Nutrition Federal University of Mato Grosso do Sul, Mato Grosso do Sul-
Descrição: dc.descriptionDepartment of Tropical Diseases Botucatu Medical School Universidade Estadual Paulista (UNESP), Botucatu-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleIron metabolism disorders of patients with chronic paracoccidioidomycosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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