A snapshot of Bothrops jararaca snake venom gland subcellular proteome

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorButantan Institute-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFIOCRUZ-
Autor(es): dc.creatorCamacho, Maurício Frota-
Autor(es): dc.creatorStuginski, Daniel R.-
Autor(es): dc.creatorAndrade-Silva, Débora-
Autor(es): dc.creatorNishiyama-Jr, Milton Y.-
Autor(es): dc.creatorValente, Richard H.-
Autor(es): dc.creatorZelanis, André-
Data de aceite: dc.date.accessioned2025-08-21T22:16:01Z-
Data de disponibilização: dc.date.available2025-08-21T22:16:01Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.biochi.2023.06.005-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300025-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300025-
Descrição: dc.descriptionSnake venom protein synthesis undergoes finely regulated processes in the specialized secretory epithelium within the venom gland. Such processes occur within a defined period in the cell and at specific cellular locations. Thus, the determination of subcellular proteomes allows the characterization of protein groups for which the site may be relevant to their biological roles, thereby allowing the deconvolution of complex biological circuits into functional information. In this regard, we performed subcellular fractionation of proteins from B. jararaca venom gland, focusing on nuclear proteins since this cellular compartment comprises key effectors that shape gene expression. Our results provided a snapshot of B. jararaca's subcellular venom gland proteome and pointed to a ‘conserved’ proteome core among different life stages (newborn and adult) and between sexes (adult male and female). Overall, the top 15 highly abundant proteins identified in B. jararaca venom glands mirrored the panel of highly expressed genes in human salivary glands. Therefore, the expression profile observed for such a protein set could be considered a conserved core signature of salivary gland secretory epithelium. Moreover, the newborn venom gland displayed a unique expression signature of transcription factors involved in regulating transcription and biosynthetic processes and may mirror biological constraints of the ontogenetic development of B. jararaca, contributing to venom proteome diversity.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFunctional Proteomics Laboratory Institute of Science and Technology Federal University of São Paulo UNIFESP, SP-
Descrição: dc.descriptionLaboratory of Herpetology Butantan Institute, SP-
Descrição: dc.descriptionTelomeres Laboratory Chemical and Biological Sciences Department IBB-UNESP, Botucatu-
Descrição: dc.descriptionLaboratory of Applied Toxinology Butantan Institute, SP-
Descrição: dc.descriptionLaboratory of Toxinology Oswaldo Cruz Institute Oswaldo Cruz Foundation FIOCRUZ, RJ-
Descrição: dc.descriptionTelomeres Laboratory Chemical and Biological Sciences Department IBB-UNESP, Botucatu-
Descrição: dc.descriptionFAPESP: # 2019/07282-8-
Descrição: dc.descriptionCNPq: # 441804/2014-4-
Descrição: dc.descriptionFAPESP: 2014/06579-3-
Formato: dc.format1-10-
Idioma: dc.languageen-
Relação: dc.relationBiochimie-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBothrops jararaca-
Palavras-chave: dc.subjectSnake venom-
Palavras-chave: dc.subjectSubcellular proteome-
Palavras-chave: dc.subjectVenom gland-
Palavras-chave: dc.subjectVenom variability-
Título: dc.titleA snapshot of Bothrops jararaca snake venom gland subcellular proteome-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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