Characterizing the Complex Multi-Step Degradation Kinetics of Amphotericin B in a Microemulsified Drug Delivery System

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Rio Grande Do Norte (UFRN)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorThe University of Iowa-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Florida-
Autor(es): dc.creatorSantos, Sarah R. A.-
Autor(es): dc.creatorAlencar, Éverton N.-
Autor(es): dc.creatorUrtiga, Silvana C. C.-
Autor(es): dc.creatorOliveira, Wógenes N.-
Autor(es): dc.creatorMiranda, Júlio Abreu-
Autor(es): dc.creatorAmaral-Machado, Lucas-
Autor(es): dc.creatorAzeredo, Francine J.-
Autor(es): dc.creatorKirsch, Lee E.-
Autor(es): dc.creatorEgito, Eryvaldo Sócrates T.-
Data de aceite: dc.date.accessioned2025-08-21T17:30:26Z-
Data de disponibilização: dc.date.available2025-08-21T17:30:26Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1208/s12249-025-03080-0-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/300024-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/300024-
Descrição: dc.descriptionAmphotericin B (AmB), a potent amphiphilic drug with antifungal and antileishmanial properties, exhibits reduced nephrotoxicity when delivered via lipid-based systems like microemulsions (ME). However, the complexity of these multi-phasic systems challenges the use of simple schemes and models for describing AmB degradation. The aim of this study was to establish a degradation scheme and model for AmB within a ME, alongside a control micellar formulation. AmB degradation pathways and models in both lipidic and aqueous systems were evaluated based on prior research. Experimental investigations into interface degradation pathways were conducted using a micellar approach. High-Performance Liquid Chromatography (HPLC) was employed for AmB quantification. Oxidation emerges as the principal degradation pathway within micelles, dependent on surfactant-induced aggregation. Considering AmB's behavior in distinct media (lipidic, aqueous, and micellar), an empirical degradation scheme is proposed, translated into a complex multi-pathway mathematical model capable of describing experimental data on AmB degradation in ME under dark conditions. Aggregation and oxidation played significant roles, and kinetic constants were calculated for AmB in ME. The model presented here represents a significant step toward accurately describing the non-linear degradation of AmB in prospective liquid lipid-based dispersions, potentially advancing its market prospects.-
Descrição: dc.descriptionLaboratory of Dispersed Systems Federal University of Rio Grande Do Norte (UFRN), RN-
Descrição: dc.descriptionCollege of Pharmaceutical Sciences Food and Nutrition Federal University of Mato Grosso Do Sul (UFMS), MS-
Descrição: dc.descriptionDivision of Pharmaceutics and Translational Therapeutics College of Pharmacy The University of Iowa-
Descrição: dc.descriptionSchool of Pharmaceutical Science São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCenter for Pharmacometrics and Systems Pharmacology Department of Pharmaceutics University of Florida-
Descrição: dc.descriptionSchool of Pharmaceutical Science São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationAAPS PharmSciTech-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectchemical stability-
Palavras-chave: dc.subjectdegradation kinetics-
Palavras-chave: dc.subjectdegradation model-
Palavras-chave: dc.subjectmicroemulsion-
Palavras-chave: dc.subjectnanosystem-
Título: dc.titleCharacterizing the Complex Multi-Step Degradation Kinetics of Amphotericin B in a Microemulsified Drug Delivery System-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.