Uterine secretome: What do the proteins say about maternal-fetal communication in buffaloes?

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorRegistro-
Autor(es): dc.creatorCodognoto, Viviane Maria-
Autor(es): dc.creatorde Souza, Fabiana Ferreira-
Autor(es): dc.creatorCataldi, Thais Regiani-
Autor(es): dc.creatorLabate, Carlos Alberto-
Autor(es): dc.creatorde Camargo, Laíza Sartori-
Autor(es): dc.creatorScott, Caroline-
Autor(es): dc.creatorda Rosa Filho, Roberto Rodrigues-
Autor(es): dc.creatorde Carvalho, Nélcio Antonio Tonizza-
Autor(es): dc.creatorOba, Eunice-
Data de aceite: dc.date.accessioned2025-08-21T22:20:50Z-
Data de disponibilização: dc.date.available2025-08-21T22:20:50Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-05-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jprot.2023.105023-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299987-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299987-
Descrição: dc.descriptionThe aim was to compare the UF proteomics of pregnant and non-pregnant buffalo during early pregnancy. Forty-four females were submitted to hormonal estrus synchronization and randomly divided into two groups: pregnant (n = 30) and non-pregnant (n = 14). The pregnant group was artificially inseminated and divided into a further two groups: P12 (n = 15) and P18 (n = 15). Conceptus and uterine fluid samples were collected during slaughter at, respectively, 12 and 18 days after insemination. Of all the inseminated females, only eight animals in each group were pregnant, which reduced the sample of the groups to P12 (n = 8) and P18 (n = 8). The non-pregnant group was also re-divided into two groups at the end of synchronization: NP12 (n = 7) and NP18 (n = 7). The UF samples were processed for proteomic analysis. The results were submitted to multivariate and univariate analysis. A total of 1068 proteins were found in the uterine fluid in both groups. Our results describe proteins involved in the conceptus elongation and maternal recognition of pregnancy, and their action was associated with cell growth, endometrial remodeling, and modulation of immune and antioxidant protection, mechanisms necessary for embryonic maintenance in the uterine environment. Significance: Uterine fluid is a substance synthesized and secreted by the endometrium that plays essential roles during pregnancy in ruminants, contributing significantly to embryonic development. Understanding the functions that the proteins present in the UF perform during early pregnancy, a period marked by embryonic implantation, and maternal recognition of pregnancy is of fundamental importance to understanding the mechanisms necessary for the maintenance of pregnancy. The present study characterized and compared the UF proteome at the beginning of pregnancy in pregnant and non-pregnant buffaloes to correlate the functions of the proteins and the stage of development of the conceptus and unravel their processes in maternal recognition of pregnancy. The proteins found were involved in cell growth and endometrial remodeling, in addition to acting in the immunological protection of the conceptus and performing antioxidant actions necessary for establishing a pregnancy.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science Universidade Estadual Paulista UNESP, São Paulo-
Descrição: dc.descriptionLaboratório Max Feffer de Genética de Plantas Departamento de Genética Escola Superior de Agricultura Luiz de Queiroz Universidade de São Paulo-
Descrição: dc.descriptionDepartment of Animal Reproduction – School of Veterinary Medicine and Animal Science University of São Paulo, campus São Paulo-
Descrição: dc.descriptionResearch and Development Unit of Registro / Diversified Animal Science Research Center / Institute of Animal Science Registro-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science Universidade Estadual Paulista UNESP, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationJournal of Proteomics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectMaternal recognition of pregnancy-
Palavras-chave: dc.subjectProteomics-
Palavras-chave: dc.subjectUterine fluid-
Título: dc.titleUterine secretome: What do the proteins say about maternal-fetal communication in buffaloes?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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