Synergic Action of Systemic Risedronate and Local Rutherpy in Peri-implantar Repair of Ovariectomized Rats: Biomechanical and Molecular Analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorScience and Technology of São Paulo (IFSP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorInoue, Bruna Kaori Namba-
Autor(es): dc.creatorPaludetto, Laura Vidoto-
Autor(es): dc.creatorMonteiro, Naara Gabriela-
Autor(es): dc.creatorBatista, Fábio Roberto de Souza-
Autor(es): dc.creatorKitagawa, Igor Lebedenco-
Autor(es): dc.creatorda Silva, Roberto Santana-
Autor(es): dc.creatorAntoniali, Cristina-
Autor(es): dc.creatorLisboa Filho, Paulo Noronha-
Autor(es): dc.creatorOkamoto, Roberta-
Data de aceite: dc.date.accessioned2025-08-21T20:22:43Z-
Data de disponibilização: dc.date.available2025-08-21T20:22:43Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms242216153-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299903-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299903-
Descrição: dc.descriptionPostmenopausal osteoporosis and poor dietary habits can lead to overweightness and obesity. Bisphosphonates are the first-line treatment for osteoporosis. However, some studies show that they may increase the risk of osteonecrosis of the jaw. Considering the antimicrobial, angiogenic and vasodilatory potential of nitric oxide, this study aims to evaluate the local activity of this substance during the placement of surface-treated implants. Seventy-two Wistar rats were divided into three groups: SHAM (SHAM surgery), OVX + HD (ovariectomy + cafeteria diet), and OVX + HD + RIS (ovariectomy + cafeteria diet + sodium risedronate treatment), which were further subdivided according to the surface treatment of the future implant: CONV (conventional), TE10, or TE100 (TERPY at 10 or 100 μM concentration); n = 8 per subgroup. The animals underwent surgery for implant installation in the proximal tibia metaphysis and were euthanized after 28 days. Data obtained from removal torque and RT-PCR (OPG, RANKL, ALP, IBSP and VEGF expression) were subjected to statistical analysis at 5% significance level. For biomechanical analysis, TE10 produced better results in the OVX + HD group (7.4 N/cm, SD = 0.6819). Molecular analysis showed: (1) significant increase in OPG gene expression in OVX groups with TE10; (2) decreased RANKL expression in OVX + HD + RIS compared to OVX + HD; (3) significantly increased expressions of IBSP and VEGF for OVX + HD + RIS TE10. At its lowest concentration, TERPY has the potential to improve peri-implant conditions.-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP, SP-
Descrição: dc.descriptionFederal Institute of Education Science and Technology of São Paulo (IFSP), SP-
Descrição: dc.descriptionDepartment of Biomolecular Sciences Faculty of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo—USP, SP-
Descrição: dc.descriptionDepartment of Physics and Meteorology Bauru Sciences School São Paulo State University Júlio de Mesquita Filho—UNESP, SP-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP, SP-
Descrição: dc.descriptionDepartment of Physics and Meteorology Bauru Sciences School São Paulo State University Júlio de Mesquita Filho—UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbisphosphonates-
Palavras-chave: dc.subjecthigh-fat diet-
Palavras-chave: dc.subjectnitric oxide donor-
Palavras-chave: dc.subjectosteoporosis-
Título: dc.titleSynergic Action of Systemic Risedronate and Local Rutherpy in Peri-implantar Repair of Ovariectomized Rats: Biomechanical and Molecular Analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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