Annexin A12–26 hydrogel improves healing properties in an experimental skin lesion after induction of type 1 diabetes

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity College London (UCL)-
Autor(es): dc.contributorUniversity Center Padre Albino-
Autor(es): dc.contributorUnião das Faculdades dos Grandes Lagos (Unilago)-
Autor(es): dc.creatorSant´Ana, Monielle-
Autor(es): dc.creatorAmantino, Camila F.-
Autor(es): dc.creatorSilva, Rafael A.-
Autor(es): dc.creatorGil, Cristiane D.-
Autor(es): dc.creatorGreco, Karin V.-
Autor(es): dc.creatorPrimo, Fernando L.-
Autor(es): dc.creatorGirol, Ana P.-
Autor(es): dc.creatorOliani, Sonia M.-
Data de aceite: dc.date.accessioned2025-08-21T21:56:46Z-
Data de disponibilização: dc.date.available2025-08-21T21:56:46Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.biopha.2023.115230-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299902-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299902-
Descrição: dc.descriptionDiabetes mellitus (DM) is characterized by metabolic alterations that involve defects in the secretion and/or action of insulin, being responsible for several complications, such as impaired healing. Studies from our research group have shown that annexin A1 protein (AnxA1) is involved in the regulation of inflammation and cell proliferation. In light of these findings, we have developed a new technology and evaluated its effect on a wound healing in vivo model using type 1 diabetes (T1DM)-induced mice. We formulated a hydrogel containing AnxA12–26 using defined parameters such as organoleptic characteristics, pH, UV–vis spectroscopy and cytotoxicity assay. UV–vis spectroscopy confirmed the presence of the associated AnxA12–26 peptide in the three-dimensional hydrogel matrix, while the in vitro cytotoxicity assay showed excellent biocompatibility. Mice showed increased blood glucose levels, confirming the efficacy of streptozotocin (STZ) to induce T1DM. Treatment with AnxA12–26 hydrogel showed to improve diabetic wound healing, defined as complete re-epithelialization and tissue remodeling, with reduction of inflammatory infiltrate in diabetic animals. We envisage that the AnxA12–26 hydrogel, with its innovative composition and formulation be efficient on improving diabetic healing and contributing on the expansion of the therapeutic arsenal to treat diabetic wounds, at a viable cost.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionPost-Graduation in Structural and Functional Biology Federal University of São Paulo/ UNIFESP-
Descrição: dc.descriptionDepartment of Engineering of Bioprocess and Biotechnology School of Pharmaceutical Sciences São Paulo State University – UNESP, SP-
Descrição: dc.descriptionDivision of Surgery and Interventional Science University College London (UCL)-
Descrição: dc.descriptionUniversity Center Padre Albino, SP-
Descrição: dc.descriptionDepartament of Biology School of Biosciences Humanities and Exact Sciences São Paulo State University/ UNESP São José do Rio Preto-
Descrição: dc.descriptionAdvanced Research Center in Medicine (CEPAM) União das Faculdades dos Grandes Lagos (Unilago), São Paulo-
Descrição: dc.descriptionDepartment of Engineering of Bioprocess and Biotechnology School of Pharmaceutical Sciences São Paulo State University – UNESP, SP-
Descrição: dc.descriptionDepartament of Biology School of Biosciences Humanities and Exact Sciences São Paulo State University/ UNESP São José do Rio Preto-
Descrição: dc.descriptionFAPESP: 2019/19949–7-
Idioma: dc.languageen-
Relação: dc.relationBiomedicine and Pharmacotherapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDiabetes-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectProtein Annexin A1-
Palavras-chave: dc.subjectSkin lesion-
Palavras-chave: dc.subjectWound healing-
Título: dc.titleAnnexin A12–26 hydrogel improves healing properties in an experimental skin lesion after induction of type 1 diabetes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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