Hypericin supramolecular assembles: A way to increase the skin availability and photodynamic efficiency in tumor cells

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGusmão, Luiza Araújo-
Autor(es): dc.creatorRodero, Camila Fernanda-
Autor(es): dc.creatorPironi, Andressa Maria-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorPerussi, Janice Rodrigues-
Data de aceite: dc.date.accessioned2025-08-21T15:39:24Z-
Data de disponibilização: dc.date.available2025-08-21T15:39:24Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.pdpdt.2023.103858-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299898-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299898-
Descrição: dc.descriptionCyclodextrins (CDs) are molecules approved by the FDA and show promise in increasing the solubility of hydrophobic molecules and making them more available to the skin. These CDs have been used to form complexes with some photosensitizers for Photodynamic Therapy (PDT), such as Hypericin (HY). HY is a lipophilic photosensitizer known for its exceptional fluorescence and singlet oxygen quantum yield generation of over 20 % under 590 nm irradiation. In this study, we found a six-fold increase in the release of HY in vitro after complexation with β-CD. The β-CDHY assembly also demonstrated better skin retention, which is crucial for the topical application of this photosensitizer. Furthermore, the β-CD complexation led to a significant increase in the phototoxicity of HY at three different light doses (3, 6, and 10 J cm−2) due to its improved water solubility and higher in vitro accumulation (approximately two times compared with free HY) in HeLa and Vero cell lines.-
Descrição: dc.descriptionAndres Soriano Foundation-
Descrição: dc.descriptionCamille and Henry Dreyfus Foundation-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniversity of São Paulo (USP) Chemical Insititut of São Carlos (IQSC), SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionAndres Soriano Foundation: #16/22544-0-
Descrição: dc.descriptionCamille and Henry Dreyfus Foundation: #17/22758-3-
Descrição: dc.descriptionCAPES: #1764416-
Descrição: dc.descriptionFAPESP: #2019/17913-5-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationPhotodiagnosis and Photodynamic Therapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCyclodextrin-
Palavras-chave: dc.subjectDrug delivery-
Palavras-chave: dc.subjectHypericin-
Palavras-chave: dc.subjectPhotodynamic therapy-
Palavras-chave: dc.subjectSkin permeation-
Título: dc.titleHypericin supramolecular assembles: A way to increase the skin availability and photodynamic efficiency in tumor cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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