Antileishmanial activity of tetra-cationic porphyrins with peripheral Pt(II) and Pd(II) complexes mediated by photodynamic therapy

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Sergipe (UFS)-
Autor(es): dc.creatorLinares, Irwin A.P.-
Autor(es): dc.creatorUría, Maricely Sánchez-
Autor(es): dc.creatorGraminha, Marcia A.S.-
Autor(es): dc.creatorIglesias, Bernardo Almeida-
Autor(es): dc.creatorVelásquez, Angela M.A.-
Data de aceite: dc.date.accessioned2025-08-21T16:30:09Z-
Data de disponibilização: dc.date.available2025-08-21T16:30:09Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.pdpdt.2023.103641-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299891-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299891-
Descrição: dc.descriptionLeishmaniasis is a neglected disease that impacts more than one billion people in endemic areas of the globe. Several drawbacks are associated with the currently existing drugs for treatment such as low effectiveness, toxicity, and the emergence of resistant strains that demonstrate the importance of looking for novel therapeutic alternatives. Photodynamic therapy (PDT) is a promising novel alternative for cutaneous leishmaniasis treatment because its topical application avoids potential side effects generally associated with oral/parenteral application. A light-sensitive compound known as photosensitizer (PS) interacts with light and molecular oxygen to generate reactive oxygen species (ROS), which promote cell death by oxidative stress through PDT approaches. Here, for the first time, we demonstrate the antileishmanial effect of tetra-cationic porphyrins with peripheral Pt(II)- and Pd(II)-polypyridyl complexes using PDT. The isomeric tetra-cationic porphyrins in the meta positions, 3-PtTPyP, and 3-PdTPyP, exhibited the highest antiparasitic activity against promastigote (IC50-pro = 41.8 nM and 46.1 nM, respectively) and intracellular amastigote forms (IC50-ama = 27.6 nM and 38.8 nM, respectively) of L. amazonensis under white light irradiation (72 J cm–2) with high selectivity (SI > 50) for both forms of parasites regarding mammalian cells. In addition, these PS induced the cell death of parasites principally by a necrotic process in the presence of white light by mitochondrial and acidic compartments accumulation. This study showed that porphyrins 3-PtTPyP and 3-PdTPyP displayed a promising antileishmanial-PDT activity with potential application for cutaneous leishmaniasis treatment.-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara – Jaú Km 01 – s/n, Campus Ville, SP-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionLaboratory of Bioinorganic and Porphyrinic Materials Universidade Federal de Santa Maria, UFSM, Av. Roraima 1000, RS-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara – Jaú Km 01 – s/n, Campus Ville, SP-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationPhotodiagnosis and Photodynamic Therapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCutaneous leishmaniasis-
Palavras-chave: dc.subjectLeishmania acidic compartments-
Palavras-chave: dc.subjectLeishmania amazonensis-
Palavras-chave: dc.subjectMitochondria colocalization-
Palavras-chave: dc.subjectPd(ii) complexes-
Palavras-chave: dc.subjectPhotodynamic therapy-
Palavras-chave: dc.subjectPt(ii) complexes-
Palavras-chave: dc.subjectTetra-cationic porphyrins-
Título: dc.titleAntileishmanial activity of tetra-cationic porphyrins with peripheral Pt(II) and Pd(II) complexes mediated by photodynamic therapy-
Tipo de arquivo: dc.typelivro digital-
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