Effects of cigarette smoke inhalation on the immune-inflammatory profile of experimental apical periodontitis in rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Texas Rio Grande Valley-
Autor(es): dc.creatorda Silva, Ana Claudia Rodrigues-
Autor(es): dc.creatorVasques, Ana Maria Veiga-
Autor(es): dc.creatorBueno, Carlos Roberto Emerenciano-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorCintra, Luciano Tavares Ângelo-
Autor(es): dc.creatorBiguetti, Claudia Cristina-
Autor(es): dc.creatorMatsumoto, Mariza Akemi-
Autor(es): dc.creatorDezan-Junior, Eloi-
Data de aceite: dc.date.accessioned2025-08-21T21:04:32Z-
Data de disponibilização: dc.date.available2025-08-21T21:04:32Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/iej.13981-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299822-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299822-
Descrição: dc.descriptionObjective: To evaluate the effects of cigarette smoke inhalation on the immune-inflammatory profile of experimental apical periodontitis in rats. Methodology: In total, 32 male Wistar rats were divided into four groups (n = 8): AP—induced apical periodontitis; S—cigarette smoke inhalation; APS—induced AP and cigarette smoke inhalation; and C (control)—neither AP nor cigarette smoke inhalation. To induce cigarette smoke inhalation, the animals were kept in a chamber filled with tobacco smoke for 8 min thrice a day for 50 days. AP was induced 20 days after inhalation initiation by exposing their coronary pulp to their oral environment for 30 days. After animals were euthanized, their right hemimaxillae were removed for histopathological, semi-quantitative and immunohistochemical (F4/80, CD206 and iNOS) analyses. Results: Quantitative data showed a moderate number of inflammatory infiltrates in AP and an intense number in APS (p <.05). Comparing F4/80+ cells showed no statistically significant differences among groups, but we found more CD206+ cells in AP than in C and S (p >.05). INOS+ immunostaining showed a significant increase in AP and APS, when compared with C and S (p <.05). APS had more iNOS+ cells than AP (p <.05). Conclusion: Cigarette smoke inhalation worsened AP, leading to a predominantly pro- inflammatory profile in our experimental model.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartamento de Odontologia Preventiva e Restauradora Faculdade de Odontologia Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartamento de Ciências Básicas Faculdade de Odontologia de Araçatuba Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionRegenerative Medicine Research Laboratory Department of Surgery and Biomechanics School of Podiatric Medicine University of Texas Rio Grande Valley-
Descrição: dc.descriptionDepartamento de Odontologia Preventiva e Restauradora Faculdade de Odontologia Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartamento de Ciências Básicas Faculdade de Odontologia de Araçatuba Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionCNPq: 131423/2020-7-
Descrição: dc.descriptionFAPESP: 2020/06310-5-
Formato: dc.format1559-1570-
Idioma: dc.languageen-
Relação: dc.relationInternational Endodontic Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanimal model-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectmacrophages-
Palavras-chave: dc.subjectperiapical periodontitis-
Palavras-chave: dc.subjectsmokers-
Título: dc.titleEffects of cigarette smoke inhalation on the immune-inflammatory profile of experimental apical periodontitis in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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