Hamamelis virginiana L. extract presents antimicrobial and antibiofilm effects, absence of cytotoxicity, anti-inflammatory action, and potential to fight infections through the nitric oxide production by macrophages

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorEscola de Medicina-
Autor(es): dc.contributorUniversidade Anhanguera-
Autor(es): dc.creatorAmêndola, Isabela-
Autor(es): dc.creatorViegas, DAIANE DE J.-
Autor(es): dc.creatorFreitas, Eduardo T.-
Autor(es): dc.creatorDE OLIVEIRA, Jonatas R.-
Autor(es): dc.creatorDos Santos, Juliana G.-
Autor(es): dc.creatorDE OLIVEIRA, Felipe E.-
Autor(es): dc.creatorLagareiro Netto, Amandio A.-
Autor(es): dc.creatorMarcucci, Maria C.-
Autor(es): dc.creatorDE OLIVEIRA, Luciane D.-
Autor(es): dc.creatorBack-Brito, Graziella N.-
Data de aceite: dc.date.accessioned2025-08-21T20:06:32Z-
Data de disponibilização: dc.date.available2025-08-21T20:06:32Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/0001-3765202320200031-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299821-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299821-
Descrição: dc.descriptionThe potential of H. virginiana L. was evaluated against Candida spp. (C. albicans, C. dubliniensis, C. glabrata, C. guilliermondii, C. krusei, and C. tropicalis) and bacteria (Acinetobacter baumannii, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Staphylococcus aureus, and Streptococcus mutans). Effect on murine macrophages (RAW 264.7) was also evaluated with respect to cytotoxicity and production of cytokines (IL-1β and TNF-α) and nitric oxide (NO). The most effective concentrations of the extract were determined by microdilution broth. These concentrations were analyzed on biofilms, after 5 min or 24 h exposure. Cytotoxicity was performed by MTT assay and quantification of cytokines and NO by ELISA and Griess reagent, respectively. The extract acted against the planktonic forms and provided significant reductions of all the microbial biofilms; besides, showed no cytotoxic effect, except at 100 mg/mL, after 24 h exposure. There was cytokine production; however, a modulatory effect was observed in groups exposed to lipopolysaccharide (LPS) from E. coli. NO production was similar or higher than the control group. Thus, H. virginiana L. extract showed antimicrobial and antibiofilm effects; absence of cytotoxicity for RAW 264.7; anti-inflammatory action; and potential to fight infections through the NO production.-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Instituto de Ciência e Tecnologia Departamento de Biociências e Diagnóstico Bucal, Av. Engenheiro Francisco José Longo, 777, SP-
Descrição: dc.descriptionUniversidade Anhembi Morumbi Escola de Medicina, Av. Deputado Benedito Matarazzo, 4050, Jardim Aquarius, SP-
Descrição: dc.descriptionUniversidade Anhanguera, Av. Raimundo Pereira de Magalhães, 3305, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Instituto de Ciência e Tecnologia Departamento de Biociências e Diagnóstico Bucal, Av. Engenheiro Francisco José Longo, 777, SP-
Idioma: dc.languageen-
Relação: dc.relationAnais da Academia Brasileira de Ciencias-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanti-inflammatory activity-
Palavras-chave: dc.subjectAntibiofilm activity-
Palavras-chave: dc.subjectantimicrobial activity-
Palavras-chave: dc.subjectcyto-toxicity-
Palavras-chave: dc.subjectHamamelis virginiana L-
Palavras-chave: dc.subjectnitric oxide-
Título: dc.titleHamamelis virginiana L. extract presents antimicrobial and antibiofilm effects, absence of cytotoxicity, anti-inflammatory action, and potential to fight infections through the nitric oxide production by macrophages-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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