Oxidative alterations in exfoliated oral mucosa cells of patients with major depressive disorder

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSpecialized Psychosocial Care Center (CEAPS)-
Autor(es): dc.creatorMendes de Abreu, Lukas-
Autor(es): dc.creatorRodrigues da Silva, Cintia-
Autor(es): dc.creatorFerreira Bortoleto, Ana Laura-
Autor(es): dc.creatorNunes, Giovana Barros-
Autor(es): dc.creatorGracia, Matheus Martins-
Autor(es): dc.creatorTzanno Murayama, Rafael Akira-
Autor(es): dc.creatorBernabé, Daniel Galera-
Autor(es): dc.creatorMingoti, Gisele Zoccal-
Data de aceite: dc.date.accessioned2025-08-21T19:13:29Z-
Data de disponibilização: dc.date.available2025-08-21T19:13:29Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jobcr.2025.01.026-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299783-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299783-
Descrição: dc.descriptionObjectives: This study aimed to investigate oxidative stress markers in the oral mucosal cells of individuals diagnosed with major depressive disorder (MDD). Methods: A case-control design was used, including twenty patients diagnosed with MDD, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, and twenty healthy controls. Oral exfoliated cells were collected from all participants. Intracellular levels of reactive oxygen species (ROS), mitochondrial membrane potential (ΔΨm), caspase-3 and -7 activity, and reduced glutathione (GSH) were measured in Arbitrary Fluorescence Units (AFU). Results: The MDD group demonstrated significantly elevated intracellular ROS levels (p = 0.0012) and caspase-3 and -7 activity (p = 0.0171) in comparison to the control group. Additionally, a decrease in ΔΨm expression was observed in the oral cells of MDD patients (p = 0.0265), whereas GSH expression levels did not differ significantly between the two groups (p = 0.8908). Conclusions: The findings indicate heightened oxidative stress in the oral exfoliated cells of individuals with MDD. This study supports the potential use of oral cells as a non-invasive biomarker source for assessing oxidative stress in depressive disorders.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionOral Oncology Center São Paulo State University (Unesp) School of Dentistry, Campus Araçatuba-
Descrição: dc.descriptionSão Paulo State University (UNESP) Graduate Program in Veterinary Medicine School of Agrarian and Veterinary Sciences, Campus Jaboticabal-
Descrição: dc.descriptionSpecialized Psychosocial Care Center (CEAPS), Araçatuba-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St Araçatuba-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Veterinary Medicine Laboratory of Reproductive Physiology, Campus Araçatuba-
Descrição: dc.descriptionOral Oncology Center São Paulo State University (Unesp) School of Dentistry, Campus Araçatuba-
Descrição: dc.descriptionSão Paulo State University (UNESP) Graduate Program in Veterinary Medicine School of Agrarian and Veterinary Sciences, Campus Jaboticabal-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University (Unesp) School of Dentistry, 1193 José Bonifácio St Araçatuba-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Veterinary Medicine Laboratory of Reproductive Physiology, Campus Araçatuba-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2019/11174-6-
Formato: dc.format256-261-
Idioma: dc.languageen-
Relação: dc.relationJournal of Oral Biology and Craniofacial Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDepression-
Palavras-chave: dc.subjectMajor depressive disorder-
Palavras-chave: dc.subjectOral disease-
Palavras-chave: dc.subjectOral mucosa-
Palavras-chave: dc.subjectOxidative stress-
Título: dc.titleOxidative alterations in exfoliated oral mucosa cells of patients with major depressive disorder-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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