Antifungal and antibiofilm effect of duloxetine hydrochloride against Cryptococcus neoformans and Cryptococcus gattii

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPrograma de Pós-Graduação em Enfermagem-
Autor(es): dc.creatorRehem, Amanda Rodrigues-
Autor(es): dc.creatorda Gama Viveiro, Letícia Rampazzo-
Autor(es): dc.creatorDe Souza Santos, Evelyn Luzia-
Autor(es): dc.creatordo Carmo, Paulo Henrique Fonseca-
Autor(es): dc.creatorda Silva, Newton Soares-
Autor(es): dc.creatorJunqueira, Juliana Campos-
Autor(es): dc.creatorScorzoni, Liliana-
Data de aceite: dc.date.accessioned2025-08-21T16:52:08Z-
Data de disponibilização: dc.date.available2025-08-21T16:52:08Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12223-024-01164-1-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299772-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299772-
Descrição: dc.descriptionCryptococcosis is an invasive mycosis caused mainly by Cryptococcus gattii and C. neoformans and is treated with amphotericin B (AMB), fluconazole and 5-fluorocytosine. However, antifungal resistance, limited and toxic antifungal arsenal stimulate the search for therapeutic strategies such as drug repurposing. Among the repurposed drugs studied, the selective serotonin reuptake inhibitors (SSRIs) have shown activity against Cryptococcus spp. However, little is known about the antifungal effect of duloxetine hydrochloride (DH), a selective serotonin and norepinephrine reuptake inhibitor (SSNRI), against C. neoformans and C. gattii. In this study, DH inhibited the growth of several C. neoformans and C. gattii strains at concentrations ranging from 15.62 to 62.50 µg/mL. In addition, DH exhibited fungicidal activity ranging from 15.62 to 250 µg/mL. In biofilm, DH treatment reduced Cryptococcus spp. biomass at a level comparable to AMB, with a significant reduction (85%) for C. neoformans biofilms. The metabolic activity of C. neoformans and C. gattii biofilms decreased significantly (99%) after treatment with DH. Scanning electron micrographs confirmed the anti-biofilm activity of DH, as isolated cells could be observed after treatment. In conclusion, DH showed promising antifungal activity against planktonic cells and biofilms of C. neoformans and C. gattii, opening perspectives for further studies with DH in vivo.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP) Av. Engenheiro Francisco José Longo, 777 São José dos Campos-
Descrição: dc.descriptionUniversidade de Guarulhos (UNG) Programa de Pós-Graduação em Enfermagem, SP-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP) Av. Engenheiro Francisco José Longo, 777 São José dos Campos-
Formato: dc.format1247-1254-
Idioma: dc.languageen-
Relação: dc.relationFolia Microbiologica-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiofilm-
Palavras-chave: dc.subjectCryptococcus spp-
Palavras-chave: dc.subjectDrug repurposing-
Palavras-chave: dc.subjectDuloxetine hydrochloride-
Título: dc.titleAntifungal and antibiofilm effect of duloxetine hydrochloride against Cryptococcus neoformans and Cryptococcus gattii-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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