Integrated aerobic exercise with LDE-docetaxel treatment: a novel approach to combat prostate cancer progression

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Western São Paulo (UNOESTE)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorVeras, Allice Santos Cruz-
Autor(es): dc.creatorBatista, Victor Rogério Garcia-
Autor(es): dc.creatorCorreia, Rafael Ribeiro-
Autor(es): dc.creatorde Almeida Tavares, Maria Eduarda-
Autor(es): dc.creatorRubira, Rafael Jesus Gonçalves-
Autor(es): dc.creatorTavares, Elaine Rufo-
Autor(es): dc.creatorGiometti, Inês Cristina-
Autor(es): dc.creatorMaranhão, Raul Cavalcante-
Autor(es): dc.creatorTeixeira, Giovana Rampazzo-
Data de aceite: dc.date.accessioned2025-08-21T19:56:04Z-
Data de disponibilização: dc.date.available2025-08-21T19:56:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-024-60138-y-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299771-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299771-
Descrição: dc.descriptionThe variability in response to conventional prostate cancer (PC) therapies, coupled with the emergent issue of drug resistance, underscores the critical need for innovative treatment strategies. Aerobic physical exercise reduced incidence of several cancers, but the mechanism underlying these effects associated the nanoemulsion not fully understood. The application of a lipid nanoemulsion (LDE) delivery system for docetaxel (DTX), showing marked enhancement in therapeutic efficacy when combined with aerobic physical exercise. This novel intervention potentiates the antitumor activity of LDE-delivered DTX by augmenting nanoparticle internalization and inducing cell cycle arrest. Our findings reveal that this synergistic treatment not only significantly reduces prostate weight and mitigates adenocarcinoma proliferation but also attenuates anti-apoptotic BCL-2 protein expression. Concurrently, it elevates pro-apoptotic proteins and diminishes inflammatory markers. Metabolic profiling of the combined therapy group disclosed additional benefits, such as reduced lipid and plasma glucose levels. Collectively, our data illuminate the profound impact of integrating LDE-mediated DTX delivery with structured physical exercise, which together spearhead a dual-front assault on PC. This multimodal approach heralds a new paradigm in PC management, accentuating the promise of combined pharmacological and non-pharmacological interventions to elevate tumor suppressor protein activity and refine patient outcomes.-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences SBFis São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Physical Education São Paulo State University (UNESP) School of Technology and Sciences Presidente Prudente, Street Roberto Simonsen, 305, SP-
Descrição: dc.descriptionDepartment of Physics School of Technology and Applied Sciences São Paulo State University, SP-
Descrição: dc.descriptionPostgraduate Animal Science Program University of Western São Paulo (UNOESTE)-
Descrição: dc.descriptionLipid Metabolism Laboratory Heart Institute (INCOR) Medical School Hospital University of São Paulo (USP), SP-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences SBFis São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Physical Education São Paulo State University (UNESP) School of Technology and Sciences Presidente Prudente, Street Roberto Simonsen, 305, SP-
Descrição: dc.descriptionDepartment of Physics School of Technology and Applied Sciences São Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEndurance physical training-
Palavras-chave: dc.subjectLDE-
Palavras-chave: dc.subjectNanoemulsion-
Palavras-chave: dc.subjectRaman spectroscopy-
Palavras-chave: dc.subjectTaxanes-
Título: dc.titleIntegrated aerobic exercise with LDE-docetaxel treatment: a novel approach to combat prostate cancer progression-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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