Presence of polyketide synthases and nonribosomal peptide synthetase in culturable bacteria associated with Aplysina fulva and Aplysina caissara (Porifera)

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Autor(es): dc.contributorFederal University of ABC-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorRio de Janeiro State University-
Autor(es): dc.creatorRojas, Letícia Sanfilippo-
Autor(es): dc.creatorde Fernandes, Michelle Guzmán-
Autor(es): dc.creatorda Motta, Andressa Cristina Ramaglia-
Autor(es): dc.creatorCarminato, Luiza Porteiro-
Autor(es): dc.creatorZanatta, Ana Caroline-
Autor(es): dc.creatorLôbo-Hajdu, Gisele-
Autor(es): dc.creatorJimenez, Paula-
Autor(es): dc.creatorCustódio, Márcio Reis-
Autor(es): dc.creatorHardoim, Cristiane Cassiolato Pires-
Data de aceite: dc.date.accessioned2025-08-21T17:55:44Z-
Data de disponibilização: dc.date.available2025-08-21T17:55:44Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s42770-024-01588-4-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299716-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299716-
Descrição: dc.descriptionCulture-dependent and -independent studies have provided access to symbiont genes and the functions they play for host sponges. Thus, this work investigates the diversity, presence of genes of pharmacological interest, biological activities and metabolome of the bacteria isolated from the sponges Aplysina caissara and Aplysina fulva collected on the southwestern Atlantic Coast. The genes for Polyketide Synthases types I and II and Nonribosomal Peptide Synthetases were screened in more than 200 bacterial strains obtained, from which around 40% were putatively novel. Twenty-two were positive for at least one of the genes screened. Among them, 12 exhibited antimicrobial activities and one inhibited the proliferation of cancer cells. The metabolic profiles of the 22 strains were analyzed by liquid chromatography with tandem mass spectrometry and molecular network. The Global Natural Products Social Molecular Networking MolNetEnhancer workflow provided a more comprehensive understanding of the metabolic profiles. The results revealed the existence of a wide range of metabolites, however more than half of the compounds could not be identified. It was further observed that the metabolic diversity among the strains varied primarily due to the cultivation medium used. Together the results obtained here revealed the pharmacological potential of the bacteria isolated from Aplysina species.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionGraduate Program in Evolution and Diversity Federal University of ABC, Av. dos Estados, Bairro Bangu, São Paulo, 5001-
Descrição: dc.descriptionDepartment of Physiology Institute of Biosciences University of São Paulo, Rua do Matão, Travessa 14, 101-
Descrição: dc.descriptionSão Paulo State University, Praça Infante Dom Henrique s/nº, Parque Bitaru, São Paulo-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University, Rua Prof. Francisco Degni, 55, Quitandinha, São Paulo-
Descrição: dc.descriptionDepartment of Genetics Biology Institute Roberto Alcântara Gomes Rio de Janeiro State University, Rua São Francisco Xavier, 524, Maracanã-
Descrição: dc.descriptionInstitute of Marine Sciences Federal University of São Paulo, Campus Baixada Santista, Rua Dr. Carvalho de Mendonça, 144, Vila Belmiro, São Paulo-
Descrição: dc.descriptionSão Paulo State University, Praça Infante Dom Henrique s/nº, Parque Bitaru, São Paulo-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University, Rua Prof. Francisco Degni, 55, Quitandinha, São Paulo-
Descrição: dc.descriptionFAPESP: 2016/17189-7-
Descrição: dc.descriptionFAPESP: 2017/10157-5-
Descrição: dc.descriptionFAPESP: 2018/12937-0-
Descrição: dc.descriptionFAPESP: 2019/01769-2-
Descrição: dc.descriptionFAPESP: 2019/08876-9-
Formato: dc.format117-136-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBioactive compounds-
Palavras-chave: dc.subjectGNPS-
Palavras-chave: dc.subjectMolecular network-
Palavras-chave: dc.subjectNRPS-
Palavras-chave: dc.subjectPKS-
Palavras-chave: dc.subjectSponges-
Título: dc.titlePresence of polyketide synthases and nonribosomal peptide synthetase in culturable bacteria associated with Aplysina fulva and Aplysina caissara (Porifera)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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