Urinary proteomics reveals biological processes related to acute kidney injury in Bothrops atrox envenomings

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Autor(es): dc.contributorDr. Heitor Vieira Dourado Tropical Medicine Foundation-
Autor(es): dc.contributorAmazonas State University-
Autor(es): dc.contributorOswaldo Cruz Foundation-
Autor(es): dc.contributorNilton Lins University-
Autor(es): dc.contributorAmazonas Federal University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorButantan Institute-
Autor(es): dc.creatorBrasileiro-Martins, Lisele Maria-
Autor(es): dc.creatorCavalcante, Sofia Angiole-
Autor(es): dc.creatorNascimento, Thaís Pinto-
Autor(es): dc.creatorSilva-Neto, Alexandre Vilhena-
Autor(es): dc.creatorMariano Santos, Marlon Dias-
Autor(es): dc.creatorCamillo-Andrade, Amanda C.-
Autor(es): dc.creatorFischer, Juliana de Saldanha da Gama-
Autor(es): dc.creatorFerreira, Caroline Coelho-
Autor(es): dc.creatorOliveira, Lucas Barbosa-
Autor(es): dc.creatorSartim, Marco Aurelio-
Autor(es): dc.creatorCosta, Allyson Guimarães-
Autor(es): dc.creatorPucca, Manuela B.-
Autor(es): dc.creatorWen, Fan Hui-
Autor(es): dc.creatorMoura-Da-silva, Ana Maria-
Autor(es): dc.creatorSachett, Jacqueline-
Autor(es): dc.creatorCarvalho, Paulo Costa-
Autor(es): dc.creatorde Aquino, Priscila Ferreira-
Autor(es): dc.creatorMonteiro, Wuelton M.-
Data de aceite: dc.date.accessioned2025-08-21T21:07:35Z-
Data de disponibilização: dc.date.available2025-08-21T21:07:35Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pntd.0012072-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299714-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299714-
Descrição: dc.descriptionAcute kidney injury (AKI) is a critical systemic complication caused by Bothrops envenoming, a neglected health problem in the Brazilian Amazon. Understanding the underlying mechanisms leading to AKI is crucial for effectively mitigating the burden of this complication. This study aimed to characterize the urinary protein profile of Bothrops atrox snakebite victims who developed AKI. We analyzed three groups of samples collected on admission: healthy subjects (controls, n = 10), snakebite victims who developed AKI (AKI, n = 10), and those who did not evolve to AKI (No-AKI, n = 10). Using liquid-chromatography tandem mass spectrometry, we identified and quantified (label-free) 1190 proteins. A panel of 65 proteins was identified exclusively in the urine of snakebite victims, with 32 exclusives to the AKI condition. Proteins more abundant or exclusive in AKI’s urine were associated with acute phase response, endopeptidase inhibition, complement cascade, and inflammation. Notable proteins include serotransferrin, SERPINA-1, alpha-1B-glycoprotein, and NHL repeat-containing protein 3. Furthermore, evaluating previously reported biomarkers candidates for AKI and renal injury, we found retinol-binding protein, beta-2-microglobulin, cystatin-C, and hepcidin to be significant in cases of AKI induced by Bothrops envenoming. This work sheds light on physiological disturbances caused by Bothrops envenoming, highlighting potential biological processes contributing to AKI. Such insights may aid in better understanding and managing this life-threatening complication.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Amazonas-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Research Dr. Heitor Vieira Dourado Tropical Medicine Foundation-
Descrição: dc.descriptionSchool of Health Sciences Amazonas State University-
Descrição: dc.descriptionLeonidas and Maria Deane Institute Oswaldo Cruz Foundation-
Descrição: dc.descriptionStructural and Computational Proteomics Laboratory Carlos Chagas Institute Oswaldo Cruz Foundation-
Descrição: dc.descriptionDepartment of Research Nilton Lins University-
Descrição: dc.descriptionNursing School Amazonas Federal University-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University-
Descrição: dc.descriptionImmunopathology Laboratory Butantan Institute-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Amazonas: 002/ 2008-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Amazonas: 005/2019-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Amazonas: 007/2018-
Descrição: dc.descriptionCNPq: 03958/2018-9-
Idioma: dc.languageen-
Relação: dc.relationPLoS Neglected Tropical Diseases-
???dc.source???: dc.sourceScopus-
Título: dc.titleUrinary proteomics reveals biological processes related to acute kidney injury in Bothrops atrox envenomings-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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