Anthelmintic Potential of Conjugated Long-Chain Fatty Acids Isolated from the Bioluminescent Mushroom Neonothopanus gardneri

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Piaui-
Autor(es): dc.contributorPraça da Liberdade-
Autor(es): dc.contributorAlfenas MG 37130-001-
Autor(es): dc.contributorFederal University of Gioias-
Autor(es): dc.contributorUniversity of Central Lancashire-
Autor(es): dc.contributorUniversity of International Integration of Afro-Brazilian Lusophony-
Autor(es): dc.contributorUniversity of Guarulhos (NPDN-UNG)-
Autor(es): dc.contributorUniversity Brazil (NPDN-UB)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorOliveira, Maria D A-
Autor(es): dc.creatorDos S Andrade, Teresinha de Jesus A-
Autor(es): dc.creatorJunior, Joaquim S C-
Autor(es): dc.creatorLima, Nerilson Marques-
Autor(es): dc.creatorMachado, Hugo G.-
Autor(es): dc.creatorTabudravu, Jioji N.-
Autor(es): dc.creatorPinto, Francisco das Chagas L-
Autor(es): dc.creatorFukui-Silva, Lucas-
Autor(es): dc.creatorAmaro, Monique C.-
Autor(es): dc.creatorde Moraes, Josué-
Autor(es): dc.creatorSilva, Dulce Helena S-
Autor(es): dc.creatorCitó, Antônia Maria das Graças L-
Autor(es): dc.creatorFeitosa, Chistiane Mendes-
Data de aceite: dc.date.accessioned2025-08-21T19:21:17Z-
Data de disponibilização: dc.date.available2025-08-21T19:21:17Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-02-28-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acs.jnatprod.4c00546-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299689-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299689-
Descrição: dc.descriptionWith praziquantel being the sole available drug for schistosomiasis, identifying novel anthelmintic agents is imperative. A chemical investigation of the fruiting body of the bioluminescent mushroom Neonothopanus gardneri Berk. resulted in the isolation of new conjugated long-chain fatty acids (8E,10E,12S,13S)-12,13-dihydroxy-7-oxo-octadeca-8,10-dienoic acid (1) and (7S,8S,9E,11E)-7,8-dihydroxy-13-oxo-octadeca-9,11-dienoic acid (2) and three previously described compounds, (7R,8R,9Z)-7,8-dihydroxyoctadec-9-enoic acid (3), (2E)-dec-2-ene-1,10-dioic acid (4), and a ketolactone marasmeno-1,15-dione (5). Their planar structures were elucidated based on 1D and 2D NMR and MS/MS spectroscopic analyses. Compound 3 displayed significant antiparasitic activity against Schistosoma mansoni ex vivo (EC50 < 10 μM). No toxicity was observed in mammalian cells or Caenorhabditis elegans.-
Descrição: dc.descriptionDepartment of Chemistry Federal University of Piaui, Campus Ministro Petrônio Portela-
Descrição: dc.descriptionNucleus of Applied Research to Sciences-NIAC, Federal Institute of Education, Science and Technology of Maranhao-IFMA, Presidente Dutra (Maranhao), Timon, Maranhao 65635-468, Brazil-
Descrição: dc.descriptionDepartment of Chemistry Federal Institute of Piaui Praça da Liberdade, Campus Central-
Descrição: dc.descriptionInstitute of Chemistry Federal University of Alfenas Alfenas MG 37130-001-
Descrição: dc.descriptionInstitute of Chemistry Federal University of Gioias-
Descrição: dc.descriptionSchool of Natural Sciences Faculty of Science and Technology University of Central Lancashire-
Descrição: dc.descriptionInstitute of Exact Sciences and Nature University of International Integration of Afro-Brazilian Lusophony-
Descrição: dc.descriptionResearch Center on Neglected Diseases University of Guarulhos (NPDN-UNG)-
Descrição: dc.descriptionResearch Center on Neglected Diseases University Brazil (NPDN-UB)-
Descrição: dc.descriptionBiosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP), P.O. Box 355-
Descrição: dc.descriptionBiosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP), P.O. Box 355-
Formato: dc.format255-261-
Idioma: dc.languageen-
Relação: dc.relationJournal of natural products-
???dc.source???: dc.sourceScopus-
Título: dc.titleAnthelmintic Potential of Conjugated Long-Chain Fatty Acids Isolated from the Bioluminescent Mushroom Neonothopanus gardneri-
Tipo de arquivo: dc.typelivro digital-
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