Safety of lactational exposure to venlafaxine on the rat mammary gland development and carcinogenesis in F1 female offspring

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAltieri, Marcelo Augusto-
Autor(es): dc.creatorda Silva, Anielly Sarana-
Autor(es): dc.creatorda Silva Moreira, Suyane-
Autor(es): dc.creatorZapaterini, Joyce Regina-
Autor(es): dc.creatorArena, Arielle Cristina-
Autor(es): dc.creatorBarbisan, Luís Fernando-
Data de aceite: dc.date.accessioned2025-08-21T21:22:04Z-
Data de disponibilização: dc.date.available2025-08-21T21:22:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2023.108451-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299659-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299659-
Descrição: dc.descriptionThe chronic use of selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhibitors (SNRIs) may result in human gynecomastia, mammoplasia, galactorrhea, and elevated breast cancer risk. As antidepressants are frequently used for postpartum depression (PPD) treatment, this study investigated the adverse effects of lactational exposure to venlafaxine (VENL, a selective SNRI) on mammary gland development and carcinogenesis in F1 female offspring. Thus, lactating Wistar rats (F0) received VENL by oral gavage at daily doses of 3.85, 7.7, or 15.4 mg/kg (N = 9, each group) from lactational day (LD 1) until the weaning of the offspring (LD 21). F1 female offspring were euthanized for mammary gland, and ovary histological analyses on the post-natal day (PND) 22 and 30 (1 pup/litter/period, N = 9, each group). At PND 22, other females (2 pups/litter, N = 18, each group) received a single dose of carcinogen N-methyl-N-nitrosourea (MNU, 50 mg/kg) intraperitoneally (i.p.) for tumor susceptibility assay until PND 250. Tumor incidence and latency were recorded and representative tumor samples were collected for histopathology. The results indicate that lactational exposure to VENL did not alter the development of the mammary gland (epithelial ductal tree or the mean number of terminal end buds), or the ovary (weight and primary, secondary, tertiary, and Graafian follicles) in prepubertal F1 female offspring. In addition, VENL exposure did not influence tumor incidence or tumor latency in adult female offspring that received MNU. Thus, the findings of this animal study indicated that lactational VENL exposure, a period similar to human PPD, did not exert an adverse effect on the mammary gland development at the prepubertal phase or on chemically induced mammary tumorigenesis in adult F1 female rats.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences Department of Structural and Functional Biology, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Faculty of Medicine Department of Pathology, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences Department of Structural and Functional Biology, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Faculty of Medicine Department of Pathology, SP-
Descrição: dc.descriptionFAPESP: #19/02902-8-
Descrição: dc.descriptionCNPq: #306918/2021-8-
Idioma: dc.languageen-
Relação: dc.relationReproductive Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectLactational exposure-
Palavras-chave: dc.subjectMammary gland and ovary development, mammary tumors, female rat offspring-
Palavras-chave: dc.subjectVenlafaxine-
Título: dc.titleSafety of lactational exposure to venlafaxine on the rat mammary gland development and carcinogenesis in F1 female offspring-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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