Effect of geometrical modifications on the mixing and enzymatic conversion of structured lipids in internal-loop airlift bioreactors

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorScience and Technology of São Paulo (IFSP)-
Autor(es): dc.creatorde Oliveira, Daniele Gonçalves-
Autor(es): dc.creatorMazziero, Vítor Teixeira-
Autor(es): dc.creatorPicão, Bruno Willian-
Autor(es): dc.creatorRibeiro, Renata Maria de Magalhães Gomes Pontes-
Autor(es): dc.creatorEsperança, Mateus Nordi-
Autor(es): dc.creatorde Paula, Ariela Veloso-
Autor(es): dc.creatorCerri, Marcel Otavio-
Data de aceite: dc.date.accessioned2025-08-21T16:36:37Z-
Data de disponibilização: dc.date.available2025-08-21T16:36:37Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bej.2024.109316-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299627-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299627-
Descrição: dc.descriptionAirlift bioreactors present a compelling alternative for reactions utilizing immobilized enzymes, offering advantages over stirred tank and packed-bed reactors. This study proposed a new configuration for an internal-loop airlift bioreactor (1 L working volume) to produce structured triglycerides using immobilized lipases in a viscous fluid. Different internal tube configurations were studied, which varied in diameter (17.5–78.6 mm), angle (-2,0,5,10 and 12°), and the addition of a rounded bottom to the bioreactor, which improved the three-phase mixture flow. The hydrodynamic effect caused by these modifications was evaluated by studying the mixing time. The best internal tube configuration, featuring a truncated cone-shaped, exhibited a 5° angle and a 64.5-mm diameter, resulting in a mixing time of 54 s. This value was about three times less than the mixing time obtained by the standard tube (171 s) at 2 vvm. Sequentially, grape seed oil acidolysis reactions with capric acid (C10) catalyzed by the Lipozyme RM IM were performed, obtaining structured MLM triglycerides with an incorporation degree of 32.32% ± 1.01%. These results indicated good biocatalyst operational stability, with a half-life of 14.13 days. Thus, this work unveils a new configuration for an airlift bioreactor collectively driving promising advancements in structured lipid production.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Dept. of Bioprocess Engineering and Biotechnology School of Pharmaceutical Sciences Araraquara, São Paulo-
Descrição: dc.descriptionState University of Campinas (UNICAMP) School of Chemical Engineering Dept. of Materials and Engineering Bioprocesses, SP-
Descrição: dc.descriptionFederal Institute of Education Science and Technology of São Paulo (IFSP) Campus Capivari, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Dept. of Bioprocess Engineering and Biotechnology School of Pharmaceutical Sciences Araraquara, São Paulo-
Descrição: dc.descriptionFAPESP: 2017/11482-7-
Descrição: dc.descriptionFAPESP: 2020/08699-7-
Descrição: dc.descriptionFAPESP: 2020/09592-1-
Descrição: dc.descriptionCNPq: 304399/2022-1-
Idioma: dc.languageen-
Relação: dc.relationBiochemical Engineering Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAirlift bioreactor-
Palavras-chave: dc.subjectDietary triglycerides-
Palavras-chave: dc.subjectGeometric modifications-
Palavras-chave: dc.subjectImmobilized lipase-
Palavras-chave: dc.subjectMixing time-
Palavras-chave: dc.subjectMultiphase mixing-
Título: dc.titleEffect of geometrical modifications on the mixing and enzymatic conversion of structured lipids in internal-loop airlift bioreactors-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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