Is There an Ideal Concentration of Ozonized Oil for the Prevention and Modulation of Zoledronate-Induced Mandibular Osteonecrosis? A Study on Senescent Rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal Fluminense Univesity-
Autor(es): dc.contributorUniversity of Guarulhos (UnG)-
Autor(es): dc.contributorTufts University School of Dental Medicine-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorSilva, Mirela Caroline-
Autor(es): dc.creatorDelamura, Izabela Fornazari-
Autor(es): dc.creatorde Sá Simon, Maria Eloise-
Autor(es): dc.creatorBarbosa, Stefany-
Autor(es): dc.creatorTing, David Tawei-
Autor(es): dc.creatorBechara, Karen-
Autor(es): dc.creatorShibli, Jamil Awad-
Autor(es): dc.creatorMourão, Carlos Fernando-
Autor(es): dc.creatorBassi, Ana Paula Farnezi-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorFaverani, Leonardo Perez-
Data de aceite: dc.date.accessioned2025-08-21T21:51:10Z-
Data de disponibilização: dc.date.available2025-08-21T21:51:10Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jfb15120353-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299585-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299585-
Descrição: dc.descriptionThis study aimed to identify whether there is an ideal concentration for applying ozonized oil (OZ) in the post-exodontic alveoli of senescent rats treated with zoledronate (ZOL). Thirty-five female rats, aged 18 months, were divided into five groups: ZOL; ZOL+OZ500; ZOL+OZ600; ZOL+OZ700; and SAL. The groups treated with ZOL, and other concentrations of OZ received applications at a dose of 100 μg/kg, while the SAL group received saline. After three weeks of ZOL application, the animals underwent extraction of the lower first molar. Subsequently, local therapies were initiated: group ZOL+OZ500 at 500 mEq/kg; ZOL+Z600 at 600 mEq/kg; and ZOL+OZ700 at 700 mEq/kg at baseline, and on days 2 and 4 post-operation. Euthanasia was performed on day 28. The microtomographic parameter of bone volume and histometric data on the area of neoformed bone (NFBT) showed the highest values for the ZOL+OZ600 group (p < 0.05). All OZ groups had smaller areas of non-vital bone than the ZOL group (p < 0.05). The clinical appearance of the operated region showed the alveoli covered with soft tissue, particularly in the OZ groups. All the tested concentrations of OZ were able to prevent and modulate MRONJ. As it presents a greater amount of NFBT, the concentration of 600 mEq/kg seems to be ideal.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araçatuba School of Dentistry Sao Paulo State University (UNESP), Sao Paulo-
Descrição: dc.descriptionDental Research Division Department of Periodontology and Oral Implantology Federal Fluminense Univesity, Rio de Janeiro-
Descrição: dc.descriptionDental Research Division Department of Periodontology and Oral Implantology University of Guarulhos (UnG), Sao Paulo-
Descrição: dc.descriptionDepartment of Basic and Clinical Translational Sciences Tufts University School of Dental Medicine-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba School of Dentistry Sao Paulo State University (UNESP), Sao Paulo-
Descrição: dc.descriptionDepartment of Oral Diagnosis Division of Oral and Maxillofacial Surgery Piracicaba Dental School University of Campinas (UNICAMP), Sao Paulo-
Descrição: dc.descriptionOMFS School of Dentistry São Paulo State University, Sao Paulo-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araçatuba School of Dentistry Sao Paulo State University (UNESP), Sao Paulo-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba School of Dentistry Sao Paulo State University (UNESP), Sao Paulo-
Descrição: dc.descriptionOMFS School of Dentistry São Paulo State University, Sao Paulo-
Idioma: dc.languageen-
Relação: dc.relationJournal of Functional Biomaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjecthealing-
Palavras-chave: dc.subjectosteonecrosis-
Palavras-chave: dc.subjectosteonecrosis associated with bisphosphonates-
Palavras-chave: dc.subjectozone-
Título: dc.titleIs There an Ideal Concentration of Ozonized Oil for the Prevention and Modulation of Zoledronate-Induced Mandibular Osteonecrosis? A Study on Senescent Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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