AdipoRon’s Impact on Alzheimer’s Disease—A Systematic Review and Meta-Analysis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de Marília (UNIMAR)-
Autor(es): dc.contributorSchool of Food and Technology of Marília (FATEC)-
Autor(es): dc.contributorFaculdade de Medicina de Marília (FAMEMA)-
Autor(es): dc.contributorFaculdade de Medicina de São José do Rio Preto (FAMERP)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorHUN-REN-SZTE)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBarbalho, Sandra Maria-
Autor(es): dc.creatorLaurindo, Lucas Fornari-
Autor(es): dc.creatorde Oliveira Zanuso, Bárbara-
Autor(es): dc.creatorda Silva, Rebeca Maria Siqueira-
Autor(es): dc.creatorGallerani Caglioni, Lívia-
Autor(es): dc.creatorNunes Junqueira de Moraes, Victor Bruno Fonseca-
Autor(es): dc.creatorFornari Laurindo, Lívia-
Autor(es): dc.creatorDogani Rodrigues, Victória-
Autor(es): dc.creatorda Silva Camarinha Oliveira, Jéssica-
Autor(es): dc.creatorBeluce, Maria Eduarda-
Autor(es): dc.creatorPenteado Detregiachi, Cláudia Rucco-
Autor(es): dc.creatorBarbalho Lamas, Caroline-
Autor(es): dc.creatordos Santos Haber, Jesselina Francisco-
Autor(es): dc.creatorCavallari Strozze Catharin, Virgínia Maria-
Autor(es): dc.creatorQuesada, Karina-
Autor(es): dc.creatorTanaka, Masaru-
Autor(es): dc.creatorValenti, Vitor Engrácia-
Data de aceite: dc.date.accessioned2025-08-21T18:41:01Z-
Data de disponibilização: dc.date.available2025-08-21T18:41:01Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms26020484-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299575-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299575-
Descrição: dc.descriptionAlzheimer’s disease (AD) remains a leading cause of cognitive decline and mortality worldwide, characterized by neurodegeneration, synaptic deficiencies, and neuroinflammation. Despite advancements in early detection, diagnosis, and treatment, AD presents substantial challenges due to its complex pathology, heterogeneity, and the limited efficacy of current therapies. Consequently, there is a pressing need for novel therapeutic agents to target the multifaceted aspects of AD pathology, enhance current treatments, and minimize adverse effects. AdipoRon, an adiponectin receptor agonist, has garnered interest for its potential neuroprotective effects, including reducing neuroinflammation, improving mitochondrial function, and mitigating tau hyperphosphorylation. This review aimed to evaluate the effects of AdipoRon-based adiponectin replacement therapy against AD, using a comprehensive approach grounded in the PICO framework—Population, Intervention, Comparison, and Outcomes. A total of six studies were reviewed, including in vitro and in vivo investigations examining AdipoRon’s impact on various AD models. These studies involved different cell lines and transgenic mouse models, assessing various outcomes such as cognitive function, neuroinflammation, tau phosphorylation, synaptic deficiencies, and relevant molecular pathways. By synthesizing data from these studies, our review thoroughly explains AdipoRon’s neuroprotective effects, mechanisms of action, and potential as a therapeutic agent for AD. This analysis aims to highlight the current state of knowledge, identify gaps in the research, and suggest directions for future studies and clinical applications.-
Descrição: dc.descriptionDepartment of Biochemistry and Pharmacology School of Medicine Universidade de Marília (UNIMAR), Marília-
Descrição: dc.descriptionPostgraduate Program in Structural and Functional Interactions in Rehabilitation School of Medicine Universidade de Marília (UNIMAR), Marília-
Descrição: dc.descriptionDepartment of Biochemistry and Nutrition School of Food and Technology of Marília (FATEC), Marília-
Descrição: dc.descriptionUNIMAR Charity Hospital Universidade de Marília (UNIMAR), São Paulo-
Descrição: dc.descriptionDepartment of Biochemistry and Pharmacology School of Medicine Faculdade de Medicina de Marília (FAMEMA), Marília-
Descrição: dc.descriptionDepartment of Administration Associate Degree in Hospital Management Universidade de Marília (UNIMAR), Marília-
Descrição: dc.descriptionDepartment of Biochemistry and Pharmacology School of Medicine Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio, São Paulo-
Descrição: dc.descriptionDepartment of Gerontology School of Gerontology Universidade Federal de São Carlos (UFSCar), São Carlos-
Descrição: dc.descriptionDanube Neuroscience Research Laboratory HUN-REN-SZTE Neuroscience Research Group Hungarian Research Network University of Szeged HUN-REN-SZTE), Tisza Lajos Krt. 113-
Descrição: dc.descriptionAutonomic Nervous System Center School of Philosophy and Sciences São Paulo State University, São Paulo-
Descrição: dc.descriptionAutonomic Nervous System Center School of Philosophy and Sciences São Paulo State University, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectadiponectin-
Palavras-chave: dc.subjectadiponectin receptor agonist-
Palavras-chave: dc.subjectadiponectin replacement therapy-
Palavras-chave: dc.subjectAdipoRon-
Palavras-chave: dc.subjectAlzheimer’s disease-
Palavras-chave: dc.subjectcognitive impairment-
Palavras-chave: dc.subjectneurology-
Palavras-chave: dc.subjectsynaptic defects-
Título: dc.titleAdipoRon’s Impact on Alzheimer’s Disease—A Systematic Review and Meta-Analysis-
Tipo de arquivo: dc.typevídeo-
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