HLA-G Gene Variability Is Associated with Papillary Thyroid Carcinoma Morbidity and the HLA-G Protein Profile

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity Health Network-
Autor(es): dc.contributorUniversity of Toronto at Mississauga-
Autor(es): dc.contributorFederal University of Rio Grande do Norte-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBertol, Bruna C.-
Autor(es): dc.creatorDebortoli, Guilherme-
Autor(es): dc.creatorDias, Fabrício C.-
Autor(es): dc.creatorde Araújo, Jéssica N. G.-
Autor(es): dc.creatorMaia, Luana S. M.-
Autor(es): dc.creatorde Almeida, Bibiana S.-
Autor(es): dc.creatorde Figueiredo-Feitosa, Nathalie L.-
Autor(es): dc.creatorde Freitas, Luiz Carlos C.-
Autor(es): dc.creatorCastelli, Erick C.-
Autor(es): dc.creatorMendes-Junior, Celso T.-
Autor(es): dc.creatorSilbiger, Vivian N.-
Autor(es): dc.creatorMaciel, Léa M. Z.-
Autor(es): dc.creatorDonadi, Eduardo A.-
Data de aceite: dc.date.accessioned2025-08-21T18:40:47Z-
Data de disponibilização: dc.date.available2025-08-21T18:40:47Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms241612858-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299565-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299565-
Descrição: dc.descriptionHuman leukocyte antigen (HLA)-G is an immune checkpoint molecule that is highly expressed in papillary thyroid carcinoma (PTC). The HLA-G gene presents several functional polymorphisms distributed across the coding and regulatory regions (5′URR: 5′ upstream regulatory region and 3′UTR: 3′ untranslated region) and some of them may impact HLA-G expression and human malignancy. To understand the contribution of the HLA-G genetic background in PTC, we studied the HLA-G gene variability in PTC patients in association with tumor morbidity, HLA-G tissue expression, and plasma soluble (sHLA-G) levels. We evaluated 185 PTC patients and 154 healthy controls. Polymorphic sites defining coding, regulatory and extended haplotypes were characterized by sequencing analyses. HLA-G tissue expression and plasma soluble HLA-G levels were evaluated by immunohistochemistry and ELISA, respectively. Compared to the controls, the G0104a(5′URR)G*01:04:04(coding)UTR-03(3’UTR) extended haplotype was underrepresented in the PTC patients, while G0104a(5′URR)G*01:04:01(coding)UTR-03(3′UTR) was less frequent in patients with metastatic and multifocal tumors. Decreased HLA-G tissue expression and undetectable plasma sHLA-G were associated with the G010102a(5′URR)G*01:01:02:01(coding)UTR-02(3′UTR) extended haplotype. We concluded that the HLA-G variability was associated with PTC development and morbidity, as well as the magnitude of the encoded protein expression at local and systemic levels.-
Descrição: dc.descriptionPostgraduate Program of Basic and Applied Immunology Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionPrincess Margaret Cancer Centre University Health Network-
Descrição: dc.descriptionDepartment of Anthropology University of Toronto at Mississauga-
Descrição: dc.descriptionDivision of Clinical Immunology Department of Medicine Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Clinical Analysis and Toxicology Federal University of Rio Grande do Norte-
Descrição: dc.descriptionDivision of Endocrinology and Metabolism Department of Medicine Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Ophthalmology Otorhinolaryngology and Head and Neck Surgery Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionDepartment of Pathology School of Medicine São Paulo State University-
Descrição: dc.descriptionDepartamento de Química Faculdade de Filosofia Ciências e Letras de Ribeirão Preto Universidade de São Paulo-
Descrição: dc.descriptionDepartment of Pathology School of Medicine São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjecthaplotypes-
Palavras-chave: dc.subjectHLA-G-
Palavras-chave: dc.subjectpapillary thyroid carcinoma-
Título: dc.titleHLA-G Gene Variability Is Associated with Papillary Thyroid Carcinoma Morbidity and the HLA-G Protein Profile-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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