A new hydroxyapatite-alginate-gelatin biocomposite favor bone regeneration in a critical-sized calvarial defect model

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Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorCentro Universitário Maria Milza (UNIMAM)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad de Especialidades Espíritu Santo (UEES)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorCentro Brasileiro de Pesquisas Físicas (CBPF)-
Autor(es): dc.creatorSantos, Anderson Cunha Dos-
Autor(es): dc.creatorAroni, Mauricio Andres Tinajero-
Autor(es): dc.creatorPigossi, Suzane Cristina-
Autor(es): dc.creatorLopes, Maria Eduarda Scordamaia-
Autor(es): dc.creatorCerri, Paulo Sergio-
Autor(es): dc.creatorMiguel, Fúlvio Borges-
Autor(es): dc.creatorSantos, Silvia Rachel de Albuquerque-
Autor(es): dc.creatorCirelli, Joni Augusto-
Autor(es): dc.creatorRosa, Fabiana Paim-
Data de aceite: dc.date.accessioned2025-08-21T15:36:57Z-
Data de disponibilização: dc.date.available2025-08-21T15:36:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/0103-6440202405461-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299548-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299548-
Descrição: dc.descriptionThis study aimed to evaluate the osteogenic potential of hydroxyapatite (HA), Alginate (Alg), and Gelatine (Gel) composite in a critical-size defect model in rats. Twenty-four male rats were divided into three groups: a negative control with no treatment (Control group), a positive control treated with deproteinized bovine bone mineral (DBBM group), and the experimental group treated with the new HA-Alg-Gel composite (HA-Alg-Gel group). A critical size defect (8.5mm) was made in the rat's calvaria, and the bone formation was evaluated by in vivo microcomputed tomography analysis (µCT) after 1, 15, 45, and 90 days. After 90 days, the animals were euthanized and histological and histomorphometric analyses were performed. A higher proportion of mineralized tissue/biomaterial was observed in the DBBM group when compared to the HA-Alg-Gel and Control groups in the µCT analysis during all analysis periods. However, no differences were observed in the mineralized tissue/biomaterial proportion observed on day 1 (immediate postoperative) in comparison to later periods of analysis in all groups. In the histomorphometric analysis, the HA-Alg-Gel and Control groups showed higher bone formation than the DBBM group. Moreover, in histological analysis, five samples of the HA-Alg-Gal group exhibited formed bone spicules adjacent to the graft granules against only two of eight samples in the DBBM group. Both graft materials ensured the maintenance of defect bone thickness, while a tissue thickness reduction was observed in the control group. In conclusion, this study demonstrated the osteoconductive potential of HA-Alg-Gel bone graft by supporting new bone formation around its particles.-
Descrição: dc.descriptionInstituto de Ciências da Saúde (ICS) Universidade Federal da Bahia (UFBA), BA-
Descrição: dc.descriptionCentro Universitário Maria Milza (UNIMAM), BA-
Descrição: dc.descriptionDepartamento de Diagnóstico e Cirurgia – Periodontia Faculdade de Odontologia de Araraquara Universidade Estadual Paulista – UNESP, São Paulo-
Descrição: dc.descriptionUniversidad de Especialidades Espíritu Santo (UEES)-
Descrição: dc.descriptionDepartamento de Periodontia e Implantodontia Faculdade de Odontologia Universidade Federal de Uberlândia, MG-
Descrição: dc.descriptionDepartamento de Morfologia e Clínica Infantil Faculdade de Odontologia de Araraquara Universidade Estadual Paulista – UNESP, São Paulo-
Descrição: dc.descriptionLABIOMAT Centro Brasileiro de Pesquisas Físicas (CBPF), RJ-
Descrição: dc.descriptionDepartamento de Diagnóstico e Cirurgia – Periodontia Faculdade de Odontologia de Araraquara Universidade Estadual Paulista – UNESP, São Paulo-
Descrição: dc.descriptionDepartamento de Morfologia e Clínica Infantil Faculdade de Odontologia de Araraquara Universidade Estadual Paulista – UNESP, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Dental Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalginates-
Palavras-chave: dc.subjectbone regeneration-
Palavras-chave: dc.subjecthydroxyapatite-
Título: dc.titleA new hydroxyapatite-alginate-gelatin biocomposite favor bone regeneration in a critical-sized calvarial defect model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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