Candida albicans Recovered From Persistent Candidemia Exhibits Enhanced Virulence Traits

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniv Calif Los Angeles-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.creatorRibeiro, Felipe de Camargo-
Autor(es): dc.creatorKemmerich, Karoline Kristina-
Autor(es): dc.creatorGoncale, Juliana Caparroz-
Autor(es): dc.creatorJunqueira, Juliana Campos-
Autor(es): dc.creatorMannan, Mohammad-
Autor(es): dc.creatorNabeela, Sunna-
Autor(es): dc.creatorColombo, Arnaldo Lopes-
Autor(es): dc.creatorUppuluri, Priya-
Data de aceite: dc.date.accessioned2025-08-21T19:59:58Z-
Data de disponibilização: dc.date.available2025-08-21T19:59:58Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-20-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/infdis/jiae631-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299540-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299540-
Descrição: dc.descriptionCandida albicans catheter-related candidemia is largely driven by microbial adhesion and biofilm formation on central venous catheters. Cells that disperse from these biofilms can enter the bloodstream, spread to distant organs, and sustain the cycle of infection. In this study, we investigated the virulence potential of C. albicans isolates obtained from the blood of catheterized patients experiencing persistent candidemia, comparing them to isolates that were cleared from the bloodstream early in the infection. Our results show that isolates persisting in the bloodstream for 4 days or longer, despite antifungal treatment, exhibited enhanced adherence, filamentation, and biofilm formation in vitro, along with increased expression of key virulence-related genes. Notably, cells dispersed from second-generation biofilms formed by these persistent isolates displayed even more pronounced pathogenic characteristics, including improved immune evasion. Furthermore, in vivo experiments using Galleria mellonella revealed that persistent isolates were significantly more virulent than their nonpersistent counterparts. Candida albicans may enhance its pathogenic traits within the host during persistent candidemia, and these traits appear to be heritable across cell generations.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionNational Institutes of Health-
Descrição: dc.descriptionUniv Fed Sao Paulo, Dept Med, Div Infect Dis, Escola Paulista Med, Sao Paulo, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Inst Sci & Technol, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP, Brazil-
Descrição: dc.descriptionUniv Calif Los Angeles, Lundquist Inst Biomed Innovat Harbor, Med Ctr, Div Infect & Immun, Torrance, CA USA-
Descrição: dc.descriptionUniv Fed Sao Paulo, Antimicrobial Resistance Inst Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA-
Descrição: dc.descriptionSao Paulo State Univ, Inst Sci & Technol, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2017/02203-7-
Descrição: dc.descriptionFAPESP: 2021/10599-3-
Descrição: dc.descriptionFAPESP: 2021/00527-5-
Descrição: dc.descriptionFAPESP: 2022/01975-4-
Descrição: dc.descriptionNational Institutes of Health: R01AI141794-01A1-
Formato: dc.format10-
Idioma: dc.languageen-
Publicador: dc.publisherOxford Univ Press Inc-
Relação: dc.relationJournal Of Infectious Diseases-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectpersistent candidemia-
Palavras-chave: dc.subjectbiofilm dispersal-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectimmune evasion-
Palavras-chave: dc.subjectvirulence-
Título: dc.titleCandida albicans Recovered From Persistent Candidemia Exhibits Enhanced Virulence Traits-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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