Bleaching gel volume influences hydrogen peroxide diffusion, inflammation, and the presence of nitric oxide in the pulp tissue: in vitro and in vivo model

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.creatorde ALCÂNTARA, Sibele-
Autor(es): dc.creatorBenetti, Francine-
Autor(es): dc.creatorda SILVA, Lívia Maria Alves Valentim-
Autor(es): dc.creatorMachado, Nathália Evelyn da Silva-
Autor(es): dc.creatorSilva, Isabela Joane Prado-
Autor(es): dc.creatorEsteves, Lara Maria Bueno-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorCintra, Luciano Tavares Angelo-
Autor(es): dc.creatorBriso, André Luiz Fraga-
Data de aceite: dc.date.accessioned2025-08-21T19:57:16Z-
Data de disponibilização: dc.date.available2025-08-21T19:57:16Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1678-7757-2023-0265-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299535-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299535-
Descrição: dc.descriptionObjective: To assess whether bleaching gel volume influences chromatic changes, hydrogen peroxide (HP) diffusion, inflammation, and oxidative stress in the pulp tissue. Methodology: A total of 60 bovine teeth were divided into four groups, according to bleaching gel volume (n=15): without gel (WG); V30 (30 µL of 35% HP); V60 (60 µL); and V120 (120 μL). HP diffusion analysis was performed in the first session (T1). Chromatic changes (ΔE, ΔE00, and WID) were assessed after the first (T1), second (T2), third (T3) sessions, and 15 d (T4) after the end of treatment. Moreover, 20 rats were randomly divided into four groups (n=10) and their upper first molars were treated with different gel volumes: control (no treatment); V2 (2 μL of 17.5% HP); V4 (4 μL); and V8 (8 μL). After 24 h, rats were euthanized and the specimens processed for histological and immunohistochemical (nitric oxide synthase) evaluation. Data were analyzed using the Wilcoxon and Mann-Whitney tests (p<0.05). Results: In vitro (bovine teeth), chromatic changes were not influenced by bleaching gel volume, showing similar values in all groups and sessions, except for the control group (p<0.05). The V120 group had the highest HP diffusion values (p<0.05). In vivo (pulp tissue), the V4 and V8 groups showed the highest inflammatory infiltrate in the pulp and significant oxidative stress (p<0.05). Conclusion: The adverse effects on the dental pulp related to HP diffusion, pulp inflammation, and oxidative stress depend on bleaching gel volume, while the bleaching effect is not proportional to the volume used.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Odontologia Preventiva e Restauradora, SP-
Descrição: dc.descriptionUniversidade Federal de Minas Gerais Faculdade de Odontologia Departamento de Odontologia Restauradora, MG-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Ciências Básicas, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Odontologia Preventiva e Restauradora, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Ciências Básicas, SP-
Descrição: dc.descriptionCNPq: 303500/2019-0-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Oral Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDosage-
Palavras-chave: dc.subjectHydrogen peroxide-
Palavras-chave: dc.subjectNitric oxide-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectTooth bleaching-
Título: dc.titleBleaching gel volume influences hydrogen peroxide diffusion, inflammation, and the presence of nitric oxide in the pulp tissue: in vitro and in vivo model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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