Murine Extraparenchymal Neurocysticercosis: Appropriate Model for Evaluating Anthelminthic and Anti-Inflammatory Treatment Schedules

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUNAM—Universidad Nacional Autónoma de Mexico-
Autor(es): dc.contributorINNN—National Institute of Neurology and Neurosurgery-
Autor(es): dc.creatorOliveira, Vinícius Tadeu-
Autor(es): dc.creatorMartins, Tatiane de Camargo-
Autor(es): dc.creatorConceição, Renato Tavares-
Autor(es): dc.creatorGeneroso, Diego-
Autor(es): dc.creatorMachado, Vânia Maria de Vasconcelos-
Autor(es): dc.creatorBatah, Sabrina Setembre-
Autor(es): dc.creatorFabro, Alexandre Todorovic-
Autor(es): dc.creatorZanini, Marco Antônio-
Autor(es): dc.creatorSciutto, Edda-
Autor(es): dc.creatorFleury, Agnès-
Autor(es): dc.creatorHamamoto Filho, Pedro Tadao-
Data de aceite: dc.date.accessioned2025-08-21T18:02:57Z-
Data de disponibilização: dc.date.available2025-08-21T18:02:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/tropicalmed9090215-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/299523-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/299523-
Descrição: dc.descriptionBackground: Experimental models of neurocysticercosis (NCC) are helpful for an improved understanding of the pathophysiological mechanisms of human diseases and for testing novel therapeutic approaches. Controlling inflammation without reducing the effectiveness of anthelmintics is an important challenge in treating neurocysticercosis. This study investigates the effects of currently used drugs (Albendazole and Dexamethasone) in treating murine extraparenchymal NCC. Methods: Twenty-two rats were inoculated with Taenia crassiceps in the subarachnoid space. The animals underwent magnetic resonance imaging to ascertain the success of infection 3 months after inoculation. The infected animals were randomly assigned to one of the three groups (five rats each): control (no treatment), Albendazole (ABZ), or Albendazole + Dexamethasone (ABZ + DXM) for 14 days. The animals were subsequently euthanised for morphological assessment 2 weeks after the end of treatment. Results: Macroscopically integrated cysts were found in all animals. The ABZ + DXM animals demonstrated lower ventricular sizes, lymphocyte infiltration rates, and immunopositivity for IL-6, with statistical differences in lymphocytes within the arachnoid region. Conclusions: This experimental model, which has previously shown similarities to human infections, is also helpful in reproducing the morphological changes upon treatment with Albendazole and Dexamethasone.-
Descrição: dc.descriptionDepartment of Neurosciences and Mental Health Botucatu Medical School UNESP—São Paulo State University-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science UNESP—São Paulo State University-
Descrição: dc.descriptionDepartment of Pathology and Legal Medicine Ribeirão Preto Medical School USP—São Paulo University, Ribeirão Preto-
Descrição: dc.descriptionDepartment of Immunology Institute of Biomedical Investigations UNAM—Universidad Nacional Autónoma de Mexico, Ciudad de México 14269-
Descrição: dc.descriptionDepartment of Medical Genomics and Environmental Toxicology Institute of Biomedical Investigations UNAM—Universidad Nacional Autónoma de Mexico, Ciudad de México 14269-
Descrição: dc.descriptionINNN—National Institute of Neurology and Neurosurgery-
Descrição: dc.descriptionDepartment of Neurosciences and Mental Health Botucatu Medical School UNESP—São Paulo State University-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science UNESP—São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationTropical Medicine and Infectious Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalbendazole-
Palavras-chave: dc.subjectdexamethasone-
Palavras-chave: dc.subjectexperimental model-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectneurocysticercosis-
Palavras-chave: dc.subjectTaenia crassiceps-
Título: dc.titleMurine Extraparenchymal Neurocysticercosis: Appropriate Model for Evaluating Anthelminthic and Anti-Inflammatory Treatment Schedules-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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